%0 Journal Article
%A Gómez-González, Belén
%A Barroso, Sonia
%A Herrera-Moyano, Emilia
%A Aguilera, Andrés
%T Spontaneous DNA-RNA hybrids: differential impacts throughout the cell cycle.
%D 2020
%U http://hdl.handle.net/10668/15116
%X A large body of research supports that transcription plays a major role among the many sources of replicative stress contributing to genome instability. It is therefore not surprising that the DNA damage response has a role in the prevention of transcription-induced threatening events such as the formation of DNA-RNA hybrids, as we have recently found through an siRNA screening. Three major DDR pathways were defined to participate in the protection against DNA-RNA hybrids: ATM/CHK2, ATR/CHK1 and Postreplication Repair (PRR). Based on these observations, we envision different scenarios of DNA-RNA hybridization and their consequent DNA damage.
%K DNA damage response
%K DNA-RNA hybrids
%K genetic instability
%K postreplication repair
%K replicative stress
%~