RT Journal Article
T1 Mediterranean Diet and White Blood Cell Count-A Randomized Controlled Trial.
A1 Hernáez, Álvaro
A1 Lassale, Camille
A1 Castro-Barquero, Sara
A1 Babio, Nancy
A1 Ros, Emilio
A1 Castañer, Olga
A1 Tresserra-Rimbau, Anna
A1 Pintó, Xavier
A1 Martínez-González, Miguel Ángel
A1 Corella, Dolores
A1 Salas-Salvadó, Jordi
A1 Alonso-Gómez, Ángel M
A1 Lapetra, José
A1 Fiol, Miquel
A1 Gómez-Gracia, Enrique
A1 Serra-Majem, Lluis
A1 Sacanella, Emilio
A1 García-Arellano, Ana
A1 Sorlí, José V
A1 Díaz-López, Andrés
A1 Cofán, Montserrat
A1 Estruch, Ramón
K1 Mediterranean diet
K1 leukocytosis
K1 leukopenia
K1 prevention
K1 randomized controlled trial
K1 white blood cell count
AB We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36-0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10-0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29 [0.085-0.99]) and attenuated the association between leukopenia and all-cause mortality (P-interaction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals.
PB Mdpi
SN 2304-8158
YR 2021
FD 2021-06-02
LK http://hdl.handle.net/10668/18074
UL http://hdl.handle.net/10668/18074
LA en
NO Hernáez Á, Lassale C, Castro-Barquero S, Babio N,Ros E, Castañer O, et al. Mediterranean Diet and White Blood Cell Count-A Randomized Controlled Trial. Foods. 2021;10(6):1268. Published 2021 Jun 2.
NO This research was supported the Instituto de Salud Carlos III (grant numbers OBN17PI02, CD17/00122 to A.H., CB06/03/0019, CB06/03/0028, PIE14/00045_INFLAMES), Agència de Gestió d’Ajuts Universitaris i de Recerca (grant numbers 2017 SGR 222, 2017-BP-00021 to C.L.), and the Spanish Ministry of Science, Innovation, and Universities (grant number FPU17/00785 to S.C.-B.). The funders had no role in the study design, data collection and analysis, the decision to publish, or the preparation of the manuscript.
DS RISalud
RD Aug 13, 2025