%0 Journal Article
%A Hernáez, Álvaro
%A Lassale, Camille
%A Castro-Barquero, Sara
%A Babio, Nancy
%A Ros, Emilio
%A Castañer, Olga
%A Tresserra-Rimbau, Anna
%A Pintó, Xavier
%A Martínez-González, Miguel Ángel
%A Corella, Dolores
%A Salas-Salvadó, Jordi
%A Alonso-Gómez, Ángel M
%A Lapetra, José
%A Fiol, Miquel
%A Gómez-Gracia, Enrique
%A Serra-Majem, Lluis
%A Sacanella, Emilio
%A García-Arellano, Ana
%A Sorlí, José V
%A Díaz-López, Andrés
%A Cofán, Montserrat
%A Estruch, Ramón
%T Mediterranean Diet and White Blood Cell Count-A Randomized Controlled Trial.
%D 2021
%@ 2304-8158
%U http://hdl.handle.net/10668/18074
%X We aimed to assess the effects of the antioxidant-rich Mediterranean diet (MedDiet) on white blood cell count. Our study population included participants in the PREvención con DIeta MEDiterránea study (average age 67 years old, 58% women, high cardiovascular risk). We assessed whether a MedDiet intervention enriched in extra-virgin olive oil or nuts, versus a low-fat control diet, modified the incidence of leukocytosis (>11 × 109 leukocytes/L), mild leukopenia (<4.5 × 109 leukocytes/L), or severe leukopenia (<3.5 × 109 leukocytes/L) in individuals without the condition at baseline (n = 3190, n = 2925, and n = 3190, respectively). We also examined whether MedDiet modified the association between leukocyte count alterations and all-cause mortality. Both MedDiet interventions were associated with a lower risk of developing leukopenia (incidence rates: 5.06% in control diet, 3.29% in MedDiet groups combined; hazard ratio [95% confidence interval]: 0.54 [0.36-0.80]) and severe leukopenia (incidence rates: 1.26% in control diet, 0.46% in MedDiet groups combined; hazard ratio: 0.25 [0.10-0.60]). High cumulative adherence to a MedDiet was linked to lower risk of leukocytosis (incidence rates: 2.08% in quartile 1, 0.65% in quartile 4; HRQ4-Q1: 0.29 [0.085-0.99]) and attenuated the association between leukopenia and all-cause mortality (P-interaction = 0.032). In brief, MedDiet decreased the incidence of white blood cell count-related alterations in high cardiovascular risk individuals.
%K Mediterranean diet
%K leukocytosis
%K leukopenia
%K prevention
%K randomized controlled trial
%K white blood cell count
%~