RT Journal Article
T1 CD34+ Cell Selection versus Reduced-Intensity Conditioning and Unmodified Grafts for Allogeneic Hematopoietic Cell Transplantation in Patients Age >50 Years with Acute Myelogenous Leukemia and Myelodysplastic Syndrome .
A1 Barba, Pere
A1 Martino, Rodrigo
A1 Zhou, Qin
A1 Cho, Christina
A1 Castro-Malaspina, Hugo
A1 Devlin, Sean
A1 Esquirol, Albert
A1 Giralt, Sergio
A1 Jakubowski, Ann A
A1 Caballero, Dolores
A1 Maloy, Molly
A1 Papadopoulos, Esperanza B
A1 Piñana, José Luís
A1 Fox, María Laura
A1 Márquez-Malaver, Francisco J
A1 Valcárcel, David
A1 Solano, Carlos
A1 López-Corral, Lucía
A1 Sierra, Jorge
A1 Perales, Miguel-Angel
K1 Allogeneic hematopoietic cell transplantation
K1 GVHD
K1 RIC
K1 T cell depletion
AB Reduced-intensity conditioning (RIC) and T cell depletion (TCD) through CD34+ cell selection without the use of post-transplantation immunosuppression are 2 strategies used to reduce nonrelapse mortality (NRM) in older patients after allogeneic hematopoietic cell transplantation (allo-HCT). To compare the efficacy of the RIC and TCD approaches, we evaluated the outcomes of patients age >50 years with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) who underwent allo-HCT from an HLA-matched donor with one of these strategies. Baseline characteristics were comparable in the patients receiving TCD (n = 204) and those receiving RIC (n = 151), except for a higher proportion of unrelated donors (68% versus 40%; P 50 years with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) who underwent allo-HCT from an HLA-matched donor with one of these strategies. Baseline characteristics were comparable in the patients receiving TCD (n = 204) and those receiving RIC (n = 151), except for a higher proportion of unrelated donors (68% versus 40%; P 50 years with AML and MDS.
YR 2018
FD 2018-01-02
LK http://hdl.handle.net/10668/11972
UL http://hdl.handle.net/10668/11972
LA en
DS RISalud
RD Apr 11, 2025