%0 Journal Article
%A Barba, Pere
%A Martino, Rodrigo
%A Zhou, Qin
%A Cho, Christina
%A Castro-Malaspina, Hugo
%A Devlin, Sean
%A Esquirol, Albert
%A Giralt, Sergio
%A Jakubowski, Ann A
%A Caballero, Dolores
%A Maloy, Molly
%A Papadopoulos, Esperanza B
%A Piñana, José Luís
%A Fox, María Laura
%A Márquez-Malaver, Francisco J
%A Valcárcel, David
%A Solano, Carlos
%A López-Corral, Lucía
%A Sierra, Jorge
%A Perales, Miguel-Angel
%T CD34+ Cell Selection versus Reduced-Intensity Conditioning and Unmodified Grafts for Allogeneic Hematopoietic Cell Transplantation in Patients Age >50 Years with Acute Myelogenous Leukemia and Myelodysplastic Syndrome .
%D 2018
%U http://hdl.handle.net/10668/11972
%X Reduced-intensity conditioning (RIC) and T cell depletion (TCD) through CD34+ cell selection without the use of post-transplantation immunosuppression are 2 strategies used to reduce nonrelapse mortality (NRM) in older patients after allogeneic hematopoietic cell transplantation (allo-HCT). To compare the efficacy of the RIC and TCD approaches, we evaluated the outcomes of patients age >50 years with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) who underwent allo-HCT from an HLA-matched donor with one of these strategies. Baseline characteristics were comparable in the patients receiving TCD (n = 204) and those receiving RIC (n = 151), except for a higher proportion of unrelated donors (68% versus 40%; P 50 years with acute myelogenous leukemia (AML) and myelodysplastic syndrome (MDS) who underwent allo-HCT from an HLA-matched donor with one of these strategies. Baseline characteristics were comparable in the patients receiving TCD (n = 204) and those receiving RIC (n = 151), except for a higher proportion of unrelated donors (68% versus 40%; P 50 years with AML and MDS.
%K Allogeneic hematopoietic cell transplantation
%K GVHD
%K RIC
%K T cell depletion
%~