RT Journal Article
T1 Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A "Real-Life" Study.
A1 Ortego-Jurado, Miguel
A1 Callejas-Rubio, José-Luis
A1 Ríos-Fernández, Raquel
A1 González-Moreno, Juan
A1 González Ramírez, Amanda Rocío
A1 González-Gay, Miguel A
A1 Ortego-Centeno, Norberto
K1 Enfermedades autoinmunes
K1 Índice de masa corporal
K1 Calcifediol
K1 Calcio en la dieta
K1 Colecalciferol
K1 Difosfonatos
K1 Femenino
K1 Fracturas óseas
K1 Glucocorticoides
K1 Humanos
K1 Incidencia
K1 Posmenopausia
K1 Vitamina D
K1 Vitaminas
AB Glucocorticoids (GCs) are the cornerstone of the therapy in many autoimmune and inflammatory diseases. However, it is well known that their use is a double edged sword, as their beneficial effects are associated almost universally with unwanted effects, as, for example glucocorticoid-induced osteoporosis (GIO). Over the last years, several clinical practice guidelines emphasize the need of preventing bone mass loss and reduce the incidence of fractures associated with GC use. Calcium and vitamin D supplementation, as adjunctive therapy, are included in all the practice guidelines. However, no standard vitamin D dose has been established. Several studies with postmenopausal women show that maintaining the levels above 30-33 ng/mL help improve the response to bisphosphonates. It is unknown if the response is the same in GIO, but in the clinical practice the levels are maintained at around the same values. In this study we demonstrate that patients with autoimmune diseases, undergoing glucocorticoid therapy, often present suboptimal 25(OH)D levels. Patients with higher body mass index and those receiving higher doses of glucocorticoids are at increased risk of having lower levels of 25(OH)D. In these patients, calcidiol supplementations are more effective than cholecalciferol to reach adequate 25(OH)D levels.
PB Hindawi Publishing Corporation
SN 2042-0064
YR 2015
FD 2015
LK http://hdl.handle.net/10668/2565
UL http://hdl.handle.net/10668/2565
LA en
NO Ortego-Jurado M, Callejas-Rubio JL, Ríos-Fernández R, González-Moreno J, González Ramírez AR, González-Gay MA, et al. Oral Calcidiol Is More Effective Than Cholecalciferol Supplementation to Reach Adequate 25(OH)D Levels in Patients with Autoimmune Diseases Chronically Treated with Low Doses of Glucocorticoids: A "Real-Life" Study. J Osteoporos; 2015:729451
NO Journal Article;
DS RISalud
RD Apr 11, 2025