RT Journal Article
T1 Worldwide clinical practices in perioperative antibiotic therapy for lung transplantation.
A1 Coiffard, Benjamin
A1 Prud'Homme, Eloi
A1 Hraiech, Sami
A1 Cassir, Nadim
A1 Le Pavec, Jérôme
A1 Kessler, Romain
A1 Meloni, Federica
A1 Leone, Marc
A1 Thomas, Pascal Alexandre
A1 Reynaud-Gaubert, Martine
A1 Papazian, Laurent
K1 Antibiotic therapy
K1 Bronchial colonization
K1 Lung transplantation
K1 Perioperative
K1 Survey
AB Infection is the most common cause of mortality within the first year after lung transplantation (LTx). The management of perioperative antibiotic therapy is a major issue, but little is known about worldwide practices. We sent by email a survey dealing with 5 daily clinical vignettes concerning perioperative antibiotic therapy to 180 LTx centers around the world. The invitation and a weekly reminder were sent to lung transplant specialists for a single consensus answer per center during a 3-month period. We received a total of 99 responses from 24 countries, mostly from Western Europe (n = 46) and the USA (n = 34). Systematic screening for bronchial recipient colonization before LTx was mostly performed with sputum samples (72%), regardless of the underlying lung disease. In recipients without colonization, antibiotics with activity against gram-negative bacteria resistant strains (piperacillin / tazobactam, cefepime, ceftazidime, carbapenems) were reported in 72% of the centers, and antibiotics with activity against methicillin-resistant Staphylococcus aureus (mainly vancomycin) were reported in 38% of the centers. For these recipients, the duration of antibiotics reported was 7 days (33%) or less (26%) or stopped when cultures of donor and recipients were reported negatives (12%). In recipients with previous colonization, antibiotics were adapted to the susceptibility of the most resistant strain and given for at least 14 days (67%). Practices vary widely around the world, but resistant bacterial strains are mostly targeted even if no colonization occurs. The antibiotic duration reported was longer for colonized recipients.
YR 2020
FD 2020-04-29
LK https://hdl.handle.net/10668/25453
UL https://hdl.handle.net/10668/25453
LA en
DS RISalud
RD Apr 8, 2025