RT Journal Article
T1 Anti-CA15.3 and Anti-CA125 Antibodies and Ovarian Cancer Risk: Results from the EPIC Cohort.
A1 Cramer, Daniel W
A1 Fichorova, Raina N
A1 Terry, Kathryn L
A1 Yamamoto, Hidemi
A1 Vitonis, Allison F
A1 Ardanaz, Eva
A1 Aune, Dagfinn
A1 Boeing, Heiner
A1 Brändstedt, Jenny
A1 Boutron-Ruault, Marie-Christine
A1 Chirlaque, Maria-Dolores
A1 Dorronsoro, Miren
A1 Dossus, Laure
A1 Duell, Eric J
A1 Gram, Inger T
A1 Gunter, Marc
A1 Hansen, Louise
A1 Idahl, Annika
A1 Johnson, Theron
A1 Khaw, Kay-Tee
A1 Krogh, Vittorio
A1 Kvaskoff, Marina
A1 Mattiello, Amalia
A1 Matullo, Giuseppe
A1 Merritt, Melissa A
A1 Nodin, Björn
A1 Orfanos, Philippos
A1 Onland-Moret, N Charlotte
A1 Palli, Domenico
A1 Peppa, Eleni
A1 Quirós, J Ramón
A1 Sanchez-Perez, Maria-Jose
A1 Severi, Gianluca
A1 Tjønneland, Anne
A1 Travis, Ruth C
A1 Trichopoulou, Antonia
A1 Tumino, Rosario
A1 Weiderpass, Elisabete
A1 Fortner, Renée T
A1 Kaaks, Rudolf
AB Background: Neoplastic and non-neoplastic events may raise levels of mucins, CA15.3, and CA125, and generate antibodies against them, but their impact on epithelial ovarian cancer (EOC) risk has not been fully defined.Methods: CA15.3, CA125, and IgG1 antibodies against them were measured in 806 women who developed EOC and 1,927 matched controls from the European Prospective Investigation of Nutrition and Cancer. Associations between epidemiologic factors and anti-mucin antibodies were evaluated using generalized linear models; EOC risks associated with anti-mucin antibodies, by themselves or in combination with respective antigens, were evaluated using conditional logistic regression.Results: In controls, lower antibodies against both mucins were associated with current smoking; and, in postmenopausal women, higher levels with longer oral contraceptive use and later-age-at and shorter-interval-since last birth. Lower anti-CA15.3 antibodies were associated with higher body mass and, in premenopausal women, more ovulatory cycles. Higher anti-CA15.3 and anti-CA125 antibodies were associated with higher risk for mucinous EOC occurring ≥ 3 years from enrollment. Long-term risk for serous EOC was reduced in women with low CA125 and high anti-CA125 antibodies relative to women with low concentrations of both.Conclusions: We found general support for the hypothesis that anti-mucin antibody levels correlate with risk factors for EOC. Antibodies alone or in combinations with their antigen may predict longer term risk of specific EOC types.Impact: Anti-CA125 and anti-CA15.3 antibodies alone or in perspective of antigens may be informative in the pathogenesis of EOC subtypes, but less useful for informing risk for all EOC. Cancer Epidemiol Biomarkers Prev; 27(7); 790-804. ©2018 AACR.
YR 2018
FD 2018-04-16
LK http://hdl.handle.net/10668/12355
UL http://hdl.handle.net/10668/12355
LA en
DS RISalud
RD Apr 7, 2025