%0 Journal Article
%A Shah, Neil P
%A Garcia-Gutierrez, Valentin
%A Jimenez-Velasco, Antonio
%A Larson, Sarah
%A Saussele, Susanne
%A Rea, Delphine
%A Mahon, François-Xavier
%A Levy, Moshe Yair
%A Gomez-Casares, Maria Teresa
%A Pane, Fabrizio
%A Nicolini, Franck-Emmanuel
%A Mauro, Michael J
%A Sy, Oumar
%A Martin-Regueira, Patricia
%A Lipton, Jeffrey H
%T Dasatinib discontinuation in patients with chronic-phase chronic myeloid leukemia and stable deep molecular response: the DASFREE study.
%D 2019
%U http://hdl.handle.net/10668/15255
%X Treatment-free remission (TFR) in patients with chronic myeloid leukemia in chronic phase (CML-CP) is considered a feasible option, especially with the ability of second-generation tyrosine kinase inhibitors to induce higher rates of sustained deep molecular response (DMR). DASFREE is an open-label, single-arm, multicenter phase II trial assessing TFR after dasatinib discontinuation in patients with CML-CP (N = 84). At 2 years, TFR was 46% in all patients. Multivariate analyses revealed statistically significant associations between 2-year TFR and duration of prior dasatinib (≥median; p = .0051), line of therapy (first line; p = .0138), and age (>65 years; p = .0012). No disease transformation occurred, and the most common adverse events experienced off treatment were musculoskeletal (observed in 30 patients); however, dasatinib withdrawal events were reported in nine patients (11%) by the investigator. Overall, these findings support the feasibility of discontinuing dasatinib for patients with CML-CP in sustained DMR in the first line and beyond.
%K CML-CP
%K Dasatinib
%K Deep molecular response
%K Imatinib
%K Major molecular response
%K Treatment-free remission
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