RT Journal Article
T1 Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease
A1 Moleon, Maria-Del-Carmen
A1 Martinez-Gomez, Estrella
A1 Flook, Marisa
A1 Peralta-Leal, Andreina
A1 Gallego, Juan Antonio
A1 Sanchez-Gomez, Hortensia
A1 Montilla-Ibañez, Maria Alharilla
A1 Dominguez-Durán, Emilio
A1 Soto-Varela, Andres
A1 Aran, Ismael
A1 Frejo, Lidia
A1 Lopez-Escamez, Jose A.
K1 Hearing loss
K1 Vertigo
K1 Migraine
K1 Cytokines
K1 Inflammation
K1 Vestibular disorders
K1 Trastornos migrañosos
K1 Pérdida auditiva
K1 Vértigo
K1 Citocinas
K1 Inflamación
AB Background: Meniere disease (MD) is an inner ear disorder associated with comorbidities such as autoimmune diseases or migraine. This study describes clinical and cytokine profiles in MD according to the age of onset of the condition. Methods: A cross-sectional study including 83 MD patients: 44 with early-onset MD (EOMD, <35 years old), and 39 with late-onset MD (LOMD,>50 years old), 64 patients with migraine and 55 controls was carried out. Clinical variables and cytokines levels of CCL3, CCL4, CCL18, CCL22, CXCL,1 and IL-1β were compared among thedifferent groups. Results: CCL18 levels were higher in patients with migraine or MD than in controls. Elevated levels of IL-1β were observed in 11.4% EOMD and in 10.3% LOMD patients and these levels were not dependent on the age of individuals. EOMD had a longer duration of the disease (p = 0.004) and a higher prevalence of migraine than LOMD (p = 0.045). Conclusions: Patients with EOMD have a higher prevalence of migraine than LOMD, but migraine is not associated with any cytokine profile in patients with MD. The levels of CCL18, CCL3, and CXCL4 were different between patients with MD or migraine and controls.
PB MDPI AG
YR 2021
FD 2021-09-07
LK http://hdl.handle.net/10668/3460
UL http://hdl.handle.net/10668/3460
LA en
NO Moleon MDC, Martinez-Gomez E, Flook M, Peralta-Leal A, Gallego JA, Sanchez-Gomez H, et al. Clinical and Cytokine Profile in Patients with Early and Late Onset Meniere Disease. J. Clin. Med. 2021, 10, 4052.
DS RISalud
RD Apr 5, 2025