RT Journal Article
T1 Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women.
A1 Almanza-Aguilera, Enrique
A1 Brunius, Carl
A1 Bernal-Lopez, M Rosa
A1 Garcia-Aloy, Mar
A1 Madrid-Gambin, Francisco
A1 Tinahones, Francisco J
A1 Gomez-Huelgas, Ricardo
A1 Landberg, Rikard
A1 Andres-Lacueva, Cristina
K1 NMR
K1 Hypocaloric diet
K1 Metabolically healthy obesity
K1 Metabolomics
K1 Physical activity
AB Little is known regarding metabolic benefits of weight loss (WL) on the metabolically healthy obese (MHO) patients. We aimed to examine the impact of a lifestyle weight loss (LWL) treatment on the plasma metabolomic profile in MHO individuals. Plasma samples from 57 MHO women allocated to an intensive LWL treatment group (TG, hypocaloric Mediterranean diet and regular physical activity, n = 30) or to a control group (CG, general recommendations of a healthy diet and physical activity, n = 27) were analyzed using an untargeted 1H NMR metabolomics approach at baseline, after 3 months (intervention), and 12 months (follow-up). The impact of the LWL intervention on plasma metabolome was statistically significant at 3 months but not at follow-up and included higher levels of formate and phosphocreatine and lower levels of LDL/VLDL (signals) and trimethylamine in the TG. These metabolites were also correlated with WL. Higher myo-inositol, methylguanidine, and 3-hydroxybutyrate, and lower proline, were also found in the TG; higher levels of hippurate and asparagine, and lower levels of 2-hydroxybutyrate and creatine, were associated with WL. The current findings suggest that an intensive LWL treatment, and the consequent WL, leads to an improved plasma metabolic profile in MHO women through its impact on energy, amino acid, lipoprotein, and microbial metabolism.
PB American Chemical Society
YR 2018
FD 2018-06-07
LK http://hdl.handle.net/10668/12559
UL http://hdl.handle.net/10668/12559
LA en
NO Almanza-Aguilera E, Brunius C, Bernal-Lopez MR, Garcia-Aloy M, Madrid-Gambin F, Tinahones FJ, et al. Impact in Plasma Metabolome as Effect of Lifestyle Intervention for Weight-Loss Reveals Metabolic Benefits in Metabolically Healthy Obese Women. J Proteome Res. 2018 Aug 3;17(8):2600-2610
DS RISalud
RD Apr 18, 2025