RT Journal Article
T1 RGS14414 treatment induces memory enhancement and rescues episodic memory deficits.
A1 Masmudi-Martín, Mariam
A1 Navarro-Lobato, Irene
A1 López-Aranda, Manuel F
A1 Delgado, Gloria
A1 Martín-Montañez, Elisa
A1 Quiros-Ortega, Maria E
A1 Carretero-Rey, Marta
A1 Narváez, Lucía
A1 Garcia-Garrido, Maria F
A1 Posadas, Sinforiano
A1 López-Téllez, Juan F
A1 Blanco, Eduardo
A1 Jiménez-Recuerda, Inmaculada
A1 Granados-Durán, Pablo
A1 Paez-Rueda, Jose
A1 López, Juan C
A1 Khan, Zafar U
K1 BDNF
K1 behavioral performance
K1 cognitive dysfunction
K1 memory circuit activation
K1 recovery of memory functions
AB Memory deficits affect a large proportion of the human population and are associated with aging and many neurologic, neurodegenerative, and psychiatric diseases. Treatment of this mental disorder has been disappointing because all potential candidates studied thus far have failed to produce consistent effects across various types of memory and have shown limited to no effects on memory deficits. Here, we show that the promotion of neuronal arborization through the expression of the regulator of G-protein signaling 14 of 414 amino acids (RGS14414) not only induced robust enhancement of multiple types of memory but was also sufficient for the recovery of recognition, spatial, and temporal memory, which are kinds of episodic memory that are primarily affected in patients or individuals with memory dysfunction. We observed that a surge in neuronal arborization was mediated by up-regulation of brain-derived neurotrophic factor (BDNF) signaling and that the deletion of BDNF abrogated both neuronal arborization activation and memory enhancement. The activation of BDNF-dependent neuronal arborization generated almost 2-fold increases in synapse numbers in dendrites of pyramidal neurons and in neurites of nonpyramidal neurons. This increase in synaptic connections might have evoked reorganization within neuronal circuits and eventually supported an increase in the activity of such circuits. Thus, in addition to showing the potential of RGS14414 for rescuing memory deficits, our results suggest that a boost in circuit activity could facilitate memory enhancement and the reversal of memory deficits.-Masmudi-Martín, M., Navarro-Lobato, I., López-Aranda, M. F., Delgado, G., Martín-Montañez, E., Quiros-Ortega, M. E., Carretero-Rey, M., Narváez, L., Garcia-Garrido, M. F., Posadas, S., López-Téllez, J. F., Blanco, E., Jiménez-Recuerda, I., Granados-Durán, P., Paez-Rueda, J., López, J. C., Khan, Z. U. RGS14414 treatment induces memory enhancement and rescues episodic memory deficits.
YR 2019
FD 2019-07-31
LK http://hdl.handle.net/10668/14346
UL http://hdl.handle.net/10668/14346
LA en
DS RISalud
RD Apr 8, 2025