RT Journal Article
T1 Th-2 signature in chronic airway diseases: towards the extinction of asthma-COPD overlap syndrome?
A1 Cosio, Borja G.
A1 Perez de Llano, Luis
A1 Lopez Vina, Antolin
A1 Torrego, Alfons
A1 Luis Lopez-Campos, Jose
A1 Soriano, Joan B.
A1 Martinez Moragon, Eva
A1 Luis Izquierdo, Jose
A1 Bobolea, Irina
A1 Callejas, Javier
A1 Plaza, Vicente
A1 Miravitlles, Marc
A1 Jose Soler-Catalunya, Juan
A1 CHACOS Study grp, 
K1 Obstructive pulmonary-disease
K1 Eosinophilic inflammation
K1 Sputum-eosinophilia
K1 Blood eosinophils
K1 Standardization
K1 Exacerbations
K1 Validation
K1 Medicine
AB We aimed to describe the differences and similarities between patients with chronic obstructive airway disease classified on the basis of classical diagnostic labels (asthma, chronic obstructive pulmonary disease (COPD), or asthma-COPD overlap (ACOS)) or according to the underlying inflammatory pattern (Th-2 signature, either Th-2-high or Th-2-low).We performed a cross-sectional study of patients aged >= 40 years and with a post-bronchodilator forced expiratory volume in 1 s to forced vital capacity ratio = 40 years and with a post-bronchodilator forced expiratory volume in 1 s to forced vital capacity ratio = 300 cells.mu L-1 and/or a sputum eosinophil count >= 3%.Overall, 292 patients were included in the study: 89 with COPD, 94 NSA and 109 with ACOS (44 SA and 65 with COPD-e). No differences in symptoms or exacerbation rate were found between the three groups. With regards the underlying inflammatory pattern, 94 patients (32.2%) were characterised as Th2- high and 198 (67.8%) as Th-2-low. The Th-2 signature was found in 49% of NSA, 3.3% of patients with COPD, 30% of SA and 49.3% of patients with COPD-e. This classification yielded significant differences in demographic, functional and inflammatory characteristics.We conclude that a classification based upon the inflammatory profile, irrespective of the taxonomy, provides a more clear distinction of patients with chronic obstructive airway disease.
PB European respiratory soc journals ltd
SN 0903-1936
YR 2017
FD 2017-05-01
LK http://hdl.handle.net/10668/19118
UL http://hdl.handle.net/10668/19118
LA en
DS RISalud
RD Apr 18, 2025