%0 Journal Article
%A Cosio, Borja G.
%A Perez de Llano, Luis
%A Lopez Vina, Antolin
%A Torrego, Alfons
%A Luis Lopez-Campos, Jose
%A Soriano, Joan B.
%A Martinez Moragon, Eva
%A Luis Izquierdo, Jose
%A Bobolea, Irina
%A Callejas, Javier
%A Plaza, Vicente
%A Miravitlles, Marc
%A Jose Soler-Catalunya, Juan
%A CHACOS Study grp
%T Th-2 signature in chronic airway diseases: towards the extinction of asthma-COPD overlap syndrome?
%D 2017
%@ 0903-1936
%U http://hdl.handle.net/10668/19118
%X We aimed to describe the differences and similarities between patients with chronic obstructive airway disease classified on the basis of classical diagnostic labels (asthma, chronic obstructive pulmonary disease (COPD), or asthma-COPD overlap (ACOS)) or according to the underlying inflammatory pattern (Th-2 signature, either Th-2-high or Th-2-low).We performed a cross-sectional study of patients aged >= 40 years and with a post-bronchodilator forced expiratory volume in 1 s to forced vital capacity ratio = 40 years and with a post-bronchodilator forced expiratory volume in 1 s to forced vital capacity ratio = 300 cells.mu L-1 and/or a sputum eosinophil count >= 3%.Overall, 292 patients were included in the study: 89 with COPD, 94 NSA and 109 with ACOS (44 SA and 65 with COPD-e). No differences in symptoms or exacerbation rate were found between the three groups. With regards the underlying inflammatory pattern, 94 patients (32.2%) were characterised as Th2- high and 198 (67.8%) as Th-2-low. The Th-2 signature was found in 49% of NSA, 3.3% of patients with COPD, 30% of SA and 49.3% of patients with COPD-e. This classification yielded significant differences in demographic, functional and inflammatory characteristics.We conclude that a classification based upon the inflammatory profile, irrespective of the taxonomy, provides a more clear distinction of patients with chronic obstructive airway disease.
%K Obstructive pulmonary-disease
%K Eosinophilic inflammation
%K Sputum-eosinophilia
%K Blood eosinophils
%K Standardization
%K Exacerbations
%K Validation
%K Medicine
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