TY  - JOUR
AU  - Neault, Nafisa
AU  - O'Reilly, Sean
AU  - Baig, Aiman Tariq
AU  - Plaza-Diaz, Julio
AU  - Azimi, Mehrdad
AU  - Farooq, Faraz
AU  - Baird, Stephen D
AU  - MacKenzie, Alex
PY  - 2021
DO  - 10.1371/journal.pone.0256276
UR  - https://hdl.handle.net/10668/28213
T2  - PloS one
AB  - Myotonic Dystrophy Type 1 (DM1) is the most common form of adult muscular dystrophy (~1:8000). In DM1, expansion of CTG trinucleotide repeats in the 3' untranslated region of the dystrophia myotonica protein kinase (DMPK) gene results in DMPK mRNA...
LA  - en
KW  - Case-Control Studies
KW  - Cell Nucleus
KW  - Fibroblasts
KW  - High-Throughput Screening Assays
KW  - Humans
KW  - Myotonic Dystrophy
KW  - RNA Interference
KW  - RNA Splicing
KW  - RNA, Messenger
KW  - RNA-Binding Proteins
KW  - Sarcoplasmic Reticulum Calcium-Transporting ATPases
KW  - Trinucleotide Repeat Expansion
TI  - High-throughput kinome-RNAi screen identifies protein kinase R activator (PACT) as a novel genetic modifier of CUG foci integrity in myotonic dystrophy type 1 (DM1).
TY  - research article
VL  - 16
ER  -