RT Journal Article
T1 HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation.
A1 Rosado-Sanchez, Isaac
A1 Herrero-Fernandez, Ines
A1 Genebat, Miguel
A1 Del-Romero, Jorge
A1 Riera, Melchor
A1 Podzamczer, Daniel
A1 Olalla, Julian
A1 Vidal, Francesc
A1 Muñoz-Fernandez, Mª Angeles
A1 Leal, Manuel
A1 Pacheco, Yolanda M
K1 CD4 T-cell homeostasis
K1 HIV
K1 OX40
K1 homeostatic parameters
K1 homeostatic proliferation
K1 immunodiscordant response to combined antiretroviral treatment
K1 low CD4 recovery
K1 α4β7
AB HIV-infected subjects with suboptimal CD4 restoration despite suppressive combined antiretroviral treatment (cART) (immunodiscordant subjects) have been classically characterized after a variable period of time under cART. Recently, we have reported that an increased frequency of proliferating CD4 T-cells in these subjects is already present before the cART onset. The potential contribution of peripheral compensatory homeostatic proliferation (HP) is yet unknown. We aimed to analyze the expression of HP-related cellular markers on CD4 T-cells of immunodiscordant subjects before cART. We analyzed the expression of OX40 and α4β7 on peripheral CD4 T-cells from immunodiscordant and control subjects (n = 21 each group) before cART initiation, and also on available follow-up samples (after 24 month of suppressive cART). Additionally, we tested the expression of these markers in an in vitro system for the study of human HP processes. Immunodiscordant subjects showed increased levels of OX40 and α4β7 on CD4 T-cells before cART initiation. While the cART tended to reduce these levels, immunodiscordant subjects still maintained comparatively higher levels of OX40 and α4β7 after 24 months under suppressive cART. These HP-related markers were upregulated in vitro during the human HP, especially during the fast HP. Our results are compatible with exacerbated HP processes in immunodiscordant subjects, already before the cART onset.
PB Frontiers Research Foundation
SN 1664-3224
YR 2018
FD 2018-07-18
LK http://hdl.handle.net/10668/12798
UL http://hdl.handle.net/10668/12798
LA en
NO Rosado-Sánchez I, Herrero-Fernández I, Genebat M, Del Romero J, Riera M, Podzamczer D, et al. HIV-Infected Subjects With Poor CD4 T-Cell Recovery Despite Effective Therapy Express High Levels of OX40 and α4β7 on CD4 T-Cells Prior Therapy Initiation. Front Immunol. 2018 Jul 18;9:1673.
DS RISalud
RD Apr 12, 2025