RT Journal Article
T1 Metabolic profiling and targeted lipidomics reveals a disturbed lipid profile in mothers and fetuses with intrauterine growth restriction.
A1 Miranda, Jezid
A1 Simões, Rui V
A1 Paules, Cristina
A1 Cañueto, Daniel
A1 Pardo-Cea, Miguel A
A1 García-Martín, María L
A1 Crovetto, Francesca
A1 Fuertes-Martin, Rocio
A1 Domenech, Monica
A1 Gómez-Roig, María D
A1 Eixarch, Elisenda
A1 Estruch, Ramon
A1 Hansson, Stefan R
A1 Amigó, Nuria
A1 Cañellas, Nicolau
A1 Crispi, Fatima
A1 Gratacós, Eduard
AB Fetal growth may be impaired by poor placental function or maternal conditions, each of which can influence the transfer of nutrients and oxygen from the mother to the developing fetus. Large-scale studies of metabolites (metabolomics) are key to understand cellular metabolism and pathophysiology of human conditions. Herein, maternal and cord blood plasma samples were used for NMR-based metabolic fingerprinting and profiling, including analysis of the enrichment of circulating lipid classes and subclasses, as well as the number of sub-fraction particles and their size. Changes in phosphatidylcholines and glycoproteins were prominent in growth-restricted fetuses indicating significant alterations in their abundance and biophysical properties. Lipoprotein profiles showed significantly lower plasma concentrations of cholesterol-intermediate density lipoprotein (IDL), triglycerides-IDL and high-density lipoprotein (HDL) in mothers of growth-restricted fetuses compared to controls (p 
YR 2018
FD 2018-09-11
LK http://hdl.handle.net/10668/12933
UL http://hdl.handle.net/10668/12933
LA en
DS RISalud
RD Apr 4, 2025