RT Journal Article T1 Common model of stress, anxiety, and depressive symptoms in pregnant women from seven high-income Western countries at the COVID-19 pandemic onset. A1 Lobel, Marci A1 Preis, Heidi A1 Mahaffey, Brittain A1 Schaal, Nora K A1 Yirmiya, Karen A1 Atzil, Shir A1 Reuveni, Inbal A1 Balestrieri, Matteo A1 Penengo, Chiara A1 Colli, Chiara A1 Garzitto, Marco A1 Driul, Lorenza A1 Ilska, Michalina A1 Brandt-Salmeri, Anna A1 KoƂodziej-Zaleska, Anna A1 Caparros-Gonzalez, Rafael A A1 Castro, Rita Amiel A1 La Marca-Ghaemmaghami, Pearl A1 Meyerhoff, Hannah K1 Anxiety K1 COVID-19 global pandemic K1 Depression K1 Maternal stress K1 Pregnancy K1 Women's health AB Increases in stress, anxiety, and depression among women pregnant during the COVID-19 pandemic have been reported internationally. Yet rigorous comparison of the prevalence of maternal mental health problems across countries is lacking. Moreover, whether stress is a common predictor of maternal mental health during the pandemic across countries is unknown. 8148 pregnant women from Germany, Israel, Italy, Poland, Spain, Switzerland, and the United States were enrolled in the International COVID-19 Pregnancy Experiences (I-COPE) Study between April 17 and May 31, 2020. Sociodemographic characteristics, pandemic-related stress, pregnancy-specific stress, anxiety, and depression were assessed with well-validated instruments. The magnitude of stress and mood disturbances was compared across countries. A path model predicting clinically significant levels of anxiety and depression from maternal characteristics and stress was tested for all study participants and then examined separately in each country with >200 participants. Countries differed significantly in magnitude of pandemic-related pregnancy stress and pandemic-unrelated pregnancy-specific stress, and in prevalence of clinically significant anxiety and depression levels. A well-fitting common path model for the entire sample indicated that mood and anxiety disturbances were strongly predicted by pandemic-related and pregnancy-specific stress after accounting for maternal characteristics. The model was replicated in individual countries. Although pregnant women in high-income Western countries experienced different levels of stress resulting from the COVID-19 pandemic, stress is a strong, common predictor of anxiety and depressive symptoms in these individuals. The common model can be used to inform research and clinical interventions to protect against adverse consequences of prenatal maternal stress, anxiety, and depression for mothers and infants. PB Elsevier Ltd YR 2022 FD 2022-10-28 LK http://hdl.handle.net/10668/22524 UL http://hdl.handle.net/10668/22524 LA en NO Lobel M, Preis H, Mahaffey B, Schaal NK, Yirmiya K, Atzil S, et al. Common model of stress, anxiety, and depressive symptoms in pregnant women from seven high-income Western countries at the COVID-19 pandemic onset. Soc Sci Med. 2022 Dec;315:115499. DS RISalud RD Apr 17, 2025