RT Journal Article
T1 Mechanistic modeling of the SARS-CoV-2 disease map.
A1 Rian, Kinza
A1 Esteban-Medina, Marina
A1 Hidalgo, Marta R
A1 Çubuk, Cankut
A1 Falco, Matias M
A1 Loucera, Carlos
A1 Gunyel, Devrim
A1 Ostaszewski, Marek
A1 Peña-Chilet, María
A1 Dopazo, Joaquín
K1 COVID-19
K1 Drug discovery
K1 Mechanistic modeling
K1 Signaling pathway
K1 Systems biology
AB Here we present a web interface that implements a comprehensive mechanistic model of the SARS-CoV-2 disease map. In this framework, the detailed activity of the human signaling circuits related to the viral infection, covering from the entry and replication mechanisms to the downstream consequences as inflammation and antigenic response, can be inferred from gene expression experiments. Moreover, the effect of potential interventions, such as knock-downs, or drug effects (currently the system models the effect of more than 8000 DrugBank drugs) can be studied. This freely available tool not only provides an unprecedentedly detailed view of the mechanisms of viral invasion and the consequences in the cell but has also the potential of becoming an invaluable asset in the search for efficient antiviral treatments.
SN 1756-0381
YR 2021
FD 2021-01-21
LK https://hdl.handle.net/10668/24624
UL https://hdl.handle.net/10668/24624
LA en
DS RISalud
RD Apr 6, 2025