RT Journal Article
T1 Comprehensive Long-Term Follow up of Adults with Arterial Switch Operation-European Collaboration for Prospective Outcome Research in Congenital Heart Disease (EPOCH-ASO)-Study Design and Protocols
A1 Ruperti-Repilado, Francisco Javier
A1 Ladouceur, Magalie
A1 Gallego, Pastora
A1 Dos, Laura
A1 Rueda Soriano, Joaquin
A1 Bouma, Berto
A1 Gabriel, Harald
A1 Schwerzmann, Markus
A1 Bouchardy, Judith
A1 Tobler, Daniel
A1 Greutmann, Matthias
K1 Transposition of the great arteries
K1 arterial switch operation
K1 coronary artery anomaly
K1 outcome
K1 Ventricular septal-defect
K1 Quality-of-life
K1 Great-arteries
K1 Coronary-arteries
K1 American society
K1 Pulmonary stenosis
K1 Anatomic repair
K1 Opposite sinus
K1 Aortic root
K1 Transposition
AB Background: Long-term outcomes in adults with prior arterial switch operation (ASO) have not yet been well defined. The aim of this study is to elucidate incidence and predictors of adverse cardiac outcomes in a prospectively followed cohort of adults after their ASO. Methods: The comprehensive long-term follow up of adults with ASO is a project within the European collaboration for prospective outcome research in congenital heart disease (EPOCH). It is designed as a prospective, international multicenter cohort study. Consecutive patients (age >= 16 years) with prior ASO will be included at 11 European tertiary care centers. Participants will be followed according to a standardized protocol following international recommendations, including standardized protocols for imaging and for exercise testing. Results: Main outcome measures are all-cause and cardiac-related mortality, rate of cardiac re-intervention, neo-aortic dissection, myocardial infarction, stroke, infective endocarditis, sustained atrial and ventricular arrhythmias, new-onset or worsening pulmonary hypertension or heart failure. Secondary endpoints are frequency and progression of right ventricular outflow stenosis, neo-aortic root dilatation, neo-aortic valve regurgitation and ventricular dysfunction. The impact of demographic, anatomic (e.g., coronary artery anatomy) and functional variables on the above-mentioned outcomes, as well as quality of life and incidence of pregnancy related complications will also be assessed. Conclusion: The prospective, international, multicenter EPOCH-ASO study will provide a better understanding of adverse outcomes and their predictors in adults after ASO. The results of the EPOCH-ASO study may help to optimize future care of this novel patient cohort in adult cardiology.
PB Tech science press
SN 1747-079X
YR 2020
FD 2020-01-01
LK http://hdl.handle.net/10668/19496
UL http://hdl.handle.net/10668/19496
LA en
DS RISalud
RD Apr 7, 2025