RT Journal Article
T1 Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: preliminary data from year 9 of the follow-up.
A1 Arrebola, Juan P
A1 Fernández, Mariana F
A1 Martin-Olmedo, Piedad
A1 Molina-Molina, José Manuel
A1 Sanchez-Perez, Maria-Jose
A1 Sanchez-Cantalejo, Emilio
A1 Molina-Portillo, Elena
A1 Expósito, José
A1 Bonde, Jens Peter
A1 Olea, Nicolás
K1 Persistent organic pollutants
K1 Adipose tissue
K1 Cancer
K1 Prospective study
K1 Hazard ratio
K1 Follow-up
K1 Contaminantes orgánicos
K1 Tejido adiposo
K1 estudios prospectivos
K1 Estudios de seguimiento
AB There is an increasing trend in the incidence of cancer worldwide, and it has been accepted that environmental factors account for an important proportion of the global burden. The present paper reports preliminary findings on the influence of the historical exposure to a group of persistent organic pollutants on total cancer risk, at year 9 in the follow-up of a cohort from Southern Spain. A cohort of 368 participants (median age 51 years) was recruited in 2003. Their historical exposure was estimated by analyzing residues of persistent organic pollutants in adipose tissue. Estimation of cancer incidence was based on data from a population-based cancer registry. Statistical analyses were performed using multivariable Cox-regression models. In males, PCB 153 concentrations were positively associated with total cancer risk, with an adjusted hazard ratio (95% confidence interval) of 1.20 (1.01-1.41) for an increment of 100 ng/g lipid. Our preliminary findings suggest a potential relationship between the historical exposure to persistent organic pollutants and the risk of cancer in men. However, these results should be interpreted with caution and require verification during the future follow-up of this cohort.
PB Elsevier
SN 0048-9697
YR 2014
FD 2014-12-01
LK http://hdl.handle.net/10668/1993
UL http://hdl.handle.net/10668/1993
LA en
NO Arrebola JP, Fernández MF, Martín-Olmedo P, Molina-Molina JM, Sánchez-Pérez MJ, Sánchez-Cantalejo E, et al. Adipose tissue concentrations of persistent organic pollutants and total cancer risk in an adult cohort from Southern Spain: preliminary data from year 9 of the follow-up. Sci. Total Environ. 2014; 500-501:243-9
DS RISalud
RD Apr 8, 2025