RT Journal Article
T1 The efficacy of suppressive antibiotic treatment in patients managednon-operatively for periprosthetic joint infection and a draining sinus
A1 Lensen, Karel-jan Dag Francois
A1 Escudero-sanchez, Rosa
A1 Cobo, Javier
A1 Trebse, Rihard
A1 Gubavu, Camelia
A1 Tedeschi, Sara
A1 Lomas, Jose M.
A1 Arvieux, Cedric
A1 Rodriguez-pardo, Dolors
A1 Fantoni, Massimo
A1 Pais, Maria Jose Garcia
A1 Jover, Francisco
A1 Salles, Mauro Jose Costa
A1 Sancho, Ignacio
A1 Sampedro, Marta Fernandez
A1 Soriano, Alex
A1 Wouthuyzen-bakker, Marjan
A1 ESGIAI, 
K1 Therapy
AB Objectives: Patients with prosthetic joint infections (PJIs) not suitable for curative surgery may benefit from suppressive antibiotic therapy (SAT). However, the usefulness of SAT in cases with a draining sinus has never been investigated. Methods: A multicentre, retrospective observational cohort study was performed in which patients with a PJI and a sinus tract were eligible for inclusion if managed conservatively and if sufficient follow-up data were available (i.e. at least 2 years). SAT was defined as a period of > 6 months of oral antibiotic therapy. Results: SAT was initiated in 63 of 72 (87.5 %) included patients. Implant retention during follow-up was the same in patients receiving SAT vs. no SAT (79.4 % vs. 88.9 %; p=0.68). In total, 27 % of patients using SAT experienced side effects. In addition, the occurrence of prosthetic loosening in initially fixed implants, the need for surgical debridement, or the occurrence of bacteremia during follow-up could not be fully prevented with the use of SAT, which still occurred in 42 %, 6.3 %, and 3.2 % of cases, respectively. However, the sinus tract tended to close more often (42 % vs. 13 %; p=0.14), and a higher resolution of pain was observed (35 % vs. 14 %; p=0.22) in patients receiving SAT. Conclusions: SAT is not able to fully prevent complications in patients with a draining sinus. However, it may be beneficial in a subset of patients, particularly in those with pain or the hindrance of a draining sinus. A future prospective study, including a higher number of patients not receiving SAT, is needed.
PB Copernicus gesellschaft mbh
YR 2021
FD 2021-08-17
LK https://hdl.handle.net/10668/27368
UL https://hdl.handle.net/10668/27368
LA en
DS RISalud
RD Apr 12, 2025