TY - JOUR AU - Maiwald, Christian A AU - Annink, Kim V AU - Rüdiger, Mario AU - Benders, Manon J N L AU - van Bel, Frank AU - Allegaert, Karel AU - Naulaers, Gunnar AU - Bassler, Dirk AU - Klebermaß-Schrehof, Katrin AU - Vento, Maximo AU - Guimarães, Hercilia AU - Stiris, Tom AU - Cattarossi, Luigi AU - Metsäranta, Marjo AU - Vanhatalo, Sampsa AU - Mazela, Jan AU - Metsvaht, Tuuli AU - Jacobs, Yannique AU - Franz, Axel R AU - ALBINO Study Group PY - 2019 DO - 10.1186/s12887-019-1566-8 UR - https://hdl.handle.net/10668/25279 T2 - BMC pediatrics AB - Perinatal asphyxia and resulting hypoxic-ischemic encephalopathy is a major cause of death and long-term disability in term born neonates. Up to 20,000 infants each year are affected by HIE in Europe and even more in regions with lower level of... LA - en KW - Allopurinol KW - Brain injury KW - Cerebral palsy KW - Childbirth outcome KW - Hypothermia therapy KW - Hypoxic-ischemic encephalopathy KW - Neonatal oxygen deficiency KW - Perinatal asphyxia KW - Allopurinol KW - Antimetabolites KW - Clinical Trials, Phase III as Topic KW - Combined Modality Therapy KW - Double-Blind Method KW - Gestational Age KW - Humans KW - Hypothermia, Induced KW - Hypoxia-Ischemia, Brain KW - Infant KW - Infant, Newborn KW - Multicenter Studies as Topic KW - Neurodevelopmental Disorders KW - Randomized Controlled Trials as Topic TI - Effect of allopurinol in addition to hypothermia treatment in neonates for hypoxic-ischemic brain injury on neurocognitive outcome (ALBINO): study protocol of a blinded randomized placebo-controlled parallel group multicenter trial for superiority (phase III). TY - research article VL - 19 ER -