RT Journal Article
T1 Factors influencing pathological ankle-brachial index values along the chronic kidney disease spectrum: the NEFRONA study.
A1 Arroyo, David
A1 Betriu, Angels
A1 Valls, Joan
A1 Gorriz, Jose L
A1 Pallares, Vicente
A1 Abajo, Maria
A1 Gracia, Marta
A1 Valdivielso, Jose Manuel
A1 Fernandez, Elvira
A1 Investigators from the NEFRONA study, 
K1 ankle-brachial index
K1 atheromatosis
K1 cardiovascular risk
K1 chronic kidney disease
K1 peripheral artery disease
AB The ankle-brachial index (ABI) is widely used to diagnose subclinical peripheral artery disease (PAD) in the general population, but data assessing its prevalence and related factors in different chronic kidney disease (CKD) stages are scarce. The aim of this study is to evaluate the prevalence and associated factors of pathological ABI values in CKD patients. NEFRONA is a multicentre prospective project that included 2445 CKD patients from 81 centres and 559 non-CKD subjects from 9 primary care centres across Spain. A trained team collected clinical and laboratory data, performed vascular ultrasounds and measured the ABI. PAD prevalence was higher in CKD than in controls (28.0 versus 12.3%, P  Asymptomatic PAD is very prevalent in all CKD stages, but factors related to a low or high pathological ABI differ, revealing different pathogenic pathways. Diabetes, dyslipidaemia, inflammation and mineral-bone disorders play a role in the appearance of PAD in CKD.
YR 2017
FD 2017
LK https://hdl.handle.net/10668/24969
UL https://hdl.handle.net/10668/24969
LA en
DS RISalud
RD Apr 6, 2025