RT Journal Article
T1 Effect of phenolic extracts from different extra-virgin olive oil varieties on osteoblast-like cells.
A1 Melguizo-Rodriguez, Lucia
A1 Ramos-Torrecillas, Javier
A1 Manzano-Moreno, Francisco Javier
A1 Illescas-Montes, Rebeca
A1 Rivas, Ana
A1 Ruiz, Concepcion
A1 De Luna-Bertos, Elvira
A1 Garcia-Martinez, Olga
K1 HLA-DR Antigens
K1 Olea
K1 Phenols
AB The reported incidence of osteoporosis is lower in countries in which the Mediterranean diet predominates, and this apparent relationship may be mediated by the phenolic compounds present in olive oil. The objective of this study was to determine the effect of phenolic extracts from different varieties of extra-virgin olive oil (Picual, Arbequina, Picudo, and Hojiblanca) on the differentiation, antigenic expression, and phagocytic capacity of osteoblast-like MG-63 cells. At 24 h of treatment a significant increase in phosphatase alkaline activity and significant reductions in CD54, CD80, and HLA-DR expression and in phagocytic activity were observed in comparison to untreated controls. The in vitro study performed has demonstrated that phenolic compounds from different extra virgin olive oil varieties can modulate different parameters related to osteoblast differentiation and function.
PB Public Library of Science
YR 2018
FD 2018-04-13
LK http://hdl.handle.net/10668/12400
UL http://hdl.handle.net/10668/12400
LA en
NO Melguizo-Rodríguez L, Ramos-Torrecillas J, Manzano-Moreno FJ, Illescas-Montes R, Rivas A, Ruiz C, et al. Effect of phenolic extracts from different extra-virgin olive oil varieties on osteoblast-like cells. PLoS One. 2018 Apr 26;13(4):e0196530.
NO This study was supported by the research group BIO277 (Junta de Andalucía) and Department of Nursing (University of Granada).
DS RISalud
RD Apr 19, 2025