RT Journal Article
T1 sFlt-1/PlGF for prediction of early-onset pre-eclampsia: STEPS (Study of Early Pre-eclampsia in Spain)
A1 Perales, A.
A1 Delgado, J. L.
A1 De la Calle, M.
A1 Garcia-Hernandez, J. A.
A1 Escudero, A. I.
A1 Campillos, J. M.
A1 Sarabia, M. D.
A1 Laiz, B.
A1 Duque, M.
A1 Navarro, M.
A1 Calmarza, P.
A1 Hund, M.
A1 Alvarez, F. V.
A1 STEPS investigators, 
K1 biomarker
K1 early-onset prediction
K1 hypertension
K1 PlGF
K1 pre-eclampsia
K1 sFlt-1
K1 sFlt-1/PlGF ratio
K1 Placental growth-factor
K1 Uterine artery doppler
K1 36 weeks gestation
K1 Angiogenic factors
K1 Tyrosine kinase-1
K1 Risk-factors
K1 Ratio
K1 Diagnosis
K1 Women
K1 Pregnancies
AB Objective A high ratio of soluble fms-like tyrosine kinase-1 (sFlt-1) to placental growth factor (PlGF) has been linked to pre-eclampsia (PE). We evaluated the sFlt-1/PlGF ratio as a predictive marker for early-onset PE in women at risk of PE.Methods This prospective, Spanish, multicenter study included pregnant women with a risk factor for PE, including intrauterine growth restriction, PE, eclampsia or hemolysis, elevated liver enzymes and low platelet count syndrome in previous pregnancy, pregestational diabetes or abnormal uterine artery Doppler. The primary objective was to show that the sFlt-1/PlGF ratio at 20, 24 and 28 weeks' gestation was predictive of early-onset PE (
PB Wiley
SN 0960-7692
YR 2017
FD 2017-09-01
LK https://hdl.handle.net/10668/25180
UL https://hdl.handle.net/10668/25180
LA en
DS RISalud
RD Apr 19, 2025