RT Generic
T1 A Review of Aceclofenac: Analgesic and Anti-Inflammatory Effects on Musculoskeletal Disorders
A1 Iolascon, Giovanni
A1 Gimenez, Sergio
A1 Mogyorosi, Dorottya
K1 aceclofenac
K1 NSAIDs
K1 analgesia
K1 osteoarthritis
K1 low back pain
K1 Comparative clinical-trial
K1 Double-blind
K1 Ankylosing-spondylitis
K1 Knee osteoarthritis
K1 Global burden
K1 Efficacy
K1 Diclofenac
K1 Safety
K1 Multicenter
K1 Management
AB Aceclofenac is an oral non-steroidal anti-inflammatory drug (NSAID) with antiinflammatory and analgesic properties. Although there are some differences in the authorized indications between countries, aceclofenac is mainly recommended for the treatment of inflammatory and painful processes, such as low back pain (LBP), scapulohumeral periarthritis, extraarticular rheumatism, odontalgia, and osteoarthritis (OA), rheumatoid arthritis (RA), and ankylosing spondylitis (AS). The analgesic properties and tolerability profile of aceclofenac in musculoskeletal disorders are reviewed, focusing on relevant and recent studies. The efficacy and safety comparison of aceclofenac with other analgesics and anti-inflammatory agents in OA, AS, RA, and LBP is described. Relevant studies were identified following a literature search of PubMed using the terms "aceclofenac" and "clinical trials" published from 1 Jan 1992 to 1 Jan 2020. Aceclofenac is at least as effective as other NSAIDs in reducing pain and/or improving functional capacity in chronic pain conditions (OA, AS, RA, and LBP). It is generally well tolerated and appears to have a more favorable GI profile than other NSAIDs. Thus, current evidence indicates that aceclofenac is a useful option for the management of pain and inflammation across a wide range of painful conditions.
PB Dove medical press ltd
SN 1178-7090
YR 2021
FD 2021-01-01
LK https://hdl.handle.net/10668/24779
UL https://hdl.handle.net/10668/24779
LA en
DS RISalud
RD Apr 12, 2025