TY  - JOUR
AU  - Salamero, Olga
AU  - Montesinos, Pau
AU  - Willekens, Christophe
AU  - Pérez-Simón, José Antonio
AU  - Pigneux, Arnaud
AU  - Récher, Christian
AU  - Popat, Rakesh
AU  - Carpio, Cecilia
AU  - Molinero, César
AU  - Mascaró, Cristina
AU  - Vila, Joaquim
AU  - Arévalo, M Isabel
AU  - Maes, Tamara
AU  - Buesa, Carlos
AU  - Bosch, Francesc
AU  - Somervaille, Tim C P
PY  - 2020
DO  - 10.1200/JCO.19.03250
UR  - https://hdl.handle.net/10668/27814
T2  - Journal of clinical oncology : official journal of the American Society of Clinical Oncology
AB  - Iadademstat is a novel, highly potent, and selective inhibitor of LSD1 (KDM1A), with preclinical in vitro and in vivo antileukemic activity. This study aimed to determine safety and tolerability of iadademstat as monotherapy in patients with...
LA  - en
KW  - Adult
KW  - Aged
KW  - Aged, 80 and over
KW  - Enzyme Inhibitors
KW  - Female
KW  - Histone Demethylases
KW  - Humans
KW  - Leukemia, Myeloid, Acute
KW  - Male
KW  - Middle Aged
KW  - Recurrence
TI  - First-in-Human Phase I Study of Iadademstat (ORY-1001): A First-in-Class Lysine-Specific Histone Demethylase 1A Inhibitor, in Relapsed or Refractory Acute Myeloid Leukemia.
TY  - research article
VL  - 38
ER  -