RT Journal Article
T1 Case Report: Barely Able to Speak, Can't Stop Echoing: Echolalic Dynamic Aphasia in Progressive Supranuclear Palsy
A1 Berthier, Marcelo L.
A1 Hoet, Florencia
A1 Beltrán-Corbellini, Álvaro
A1 Santana-Moreno, Daniel
A1 Edelkraut, Lisa
A1 Dávila, Guadalupe
K1 Dynamic aphasia
K1 Echolalia
K1 Progressive supranuclear palsy
K1 Primary progressive aphasia
K1 Inhibition deficits
K1 Apathy
K1 Comprehension
K1 Atrophy
K1 Afasia
K1 Ecolalia
K1 Parálisis supranuclear progresiva
K1 Afasia progresiva primaria
K1 Apatía
K1 Comprensión
K1 Atrofia
K1 Patología del habla y lenguaje
AB The diagnostic criteria for progressive supranuclear palsy (PSP) incorporate two speech-language disturbances (SLDs), non-fluent/agrammatic primary progressive aphasia and progressive apraxia of speech, but overlook the inclusion of other SLDs, including dynamic aphasia (DA). Thus, there is a need to reappraise the broad spectrum of SLDs in PSP to include other presenting phenotypes. Here we report findings from the study of two elderly patients with PSP presenting with DA and irrepressible echolalia. Both patients had markedly impoverished verbal production, but their performance in other tasks (repetition and naming) and auditory comprehension were preserved or only mildly impaired. Experimental tests of DA revealed impaired word and sentence generation in response to verbal and non-verbal stimuli. Additional language and cognitive testing revealed different types of echolalia (mitigated, automatic, and echoing approval) as well as impaired inhibitory control and social cognition (mentalizing). Both patients had negative neuropsychiatric alterations (i.e., apathy, aspontaneity, and indifference/emotional flatness). Brain magnetic resonance imaging in both patients showed atrophy of the midbrain tegmentum and superior medial frontal cortex suggestive of PSP, yet further evaluation of the neural correlates using multimodal neuroimaging and neuropathological data was not performed. However, based on the already known neural basis of DA and echolalia in PSP and stroke, we suggest that, in the present cases, neurodegeneration in the midbrain tegmentum, superior medial frontal lobe, and caudate nucleus was responsible for DA and that decreased activity in these regions may play a permissive role for eliciting verbal echoing via disinhibition of the perisylvian speech-language network.
PB Frontiers
YR 2021
FD 2021-05-04
LK http://hdl.handle.net/10668/4482
UL http://hdl.handle.net/10668/4482
LA en
NO Berthier ML, Hoet F, Beltrán-Corbellini Á, Santana-Moreno D, Edelkraut L, Dávila G. Case Report: Barely Able to Speak, Can't Stop Echoing: Echolalic Dynamic Aphasia in Progressive Supranuclear Palsy. Front Aging Neurosci. 2021 May 4;13:635896
DS RISalud
RD Apr 6, 2025