RT Journal Article
T1 Impact of chronic obstructive pulmonary disease on short-term outcome in patients with ST-elevation myocardial infarction during COVID-19 pandemic: insights from the international multicenter ISACS-STEMI registry.
A1 De Luca, Giuseppe
A1 Nardin, Matteo
A1 Algowhary, Magdy
A1 Uguz, Berat
A1 Oliveira, Dinaldo C
A1 Ganyukov, Vladimir
A1 Zimbakov, Zan
A1 Cercek, Miha
A1 Okkels Jensen, Lisette
A1 Loh, Poay Huan
A1 Calmac, Lucian
A1 Roura Ferrer, Gerard
A1 Quadros, Alexandre
A1 Milewski, Marek
A1 Scotto di Uccio, Fortunato
A1 von Birgelen, Clemens
A1 Versaci, Francesco
A1 Ten Berg, Jurrien
A1 Casella, Gianni
A1 Wong Sung Lung, Aaron
A1 Kala, Petr
A1 Díez Gil, José Luis
A1 Carrillo, Xavier
A1 Dirksen, Maurits
A1 Becerra-Munoz, Victor M
A1 Lee, Michael Kang-Yin
A1 Arifa Juzar, Dafsah
A1 de Moura Joaquim, Rodrigo
A1 Paladino, Roberto
A1 Milicic, Davor
A1 Davlouros, Periklis
A1 Bakraceski, Nikola
A1 Zilio, Filippo
A1 Donazzan, Luca
A1 Kraaijeveld, Adriaan
A1 Galasso, Gennaro
A1 Lux, Arpad
A1 Marinucci, Lucia
A1 Guiducci, Vincenzo
A1 Menichelli, Maurizio
A1 Scoccia, Alessandra
A1 Yamac, Aylin Hatice
A1 Ugur Mert, Kadir
A1 Flores Rios, Xacobe
A1 Kovarnik, Tomas
A1 Kidawa, Michal
A1 Moreu, Josè
A1 Flavien, Vincent
A1 Fabris, Enrico
A1 Martínez-Luengas, Iñigo Lozano
A1 Boccalatte, Marco
A1 Bosa Ojeda, Francisco
A1 Arellano-Serrano, Carlos
A1 Caiazzo, Gianluca
A1 Cirrincione, Giuseppe
A1 Kao, Hsien-Li
A1 Sanchis Forés, Juan
A1 Vignali, Luigi
A1 Pereira, Helder
A1 Manzo, Stephane
A1 Ordoñez, Santiago
A1 Özkan, Alev Arat
A1 Scheller, Bruno
A1 Lehtola, Heidi
A1 Teles, Rui
A1 Mantis, Christos
A1 Antti, Ylitalo
A1 Brum Silveira, João A
A1 Zoni, Rodrigo
A1 Bessonov, Ivan
A1 Savonitto, Stefano
A1 Kochiadakis, George
A1 Alexopoulos, Dimitrios
A1 Uribe, Carlos E
A1 Kanakakis, John
A1 Faurie, Benjamin
A1 Gabrielli, Gabriele
A1 Gutierrez Barrios, Alejandro
A1 Bachini, Juan Pablo
A1 Rocha, Alex
A1 Tam, Frankie Chor-Cheung
A1 Rodriguez, Alfredo
A1 Lukito, Antonia Anna
A1 Saint-Joy, Veauthyelau
A1 Pessah, Gustavo
A1 Tuccillo, Andrea
A1 Cortese, Giuliana
A1 Parodi, Guido
A1 Bouraghda, Mohamed Abed
A1 Kedhi, Elvin
A1 Lamelas, Pablo
A1 Suryapranata, Harry
A1 Verdoia, Monica
K1 COPD
K1 Mortality
K1 STEMI
AB Chronic obstructive pulmonary disease (COPD) is projected to become the third cause of mortality worldwide. COPD shares several pathophysiological mechanisms with cardiovascular disease, especially atherosclerosis. However, no definite answers are available on the prognostic role of COPD in the setting of ST elevation myocardial infarction (STEMI), especially during COVID-19 pandemic, among patients undergoing primary angioplasty, that is therefore the aim of the current study. In the ISACS-STEMI COVID-19 registry we included retrospectively patients with STEMI treated with primary percutaneous coronary intervention (PCI) between March and June of 2019 and 2020 from 109 high-volume primary PCI centers in 4 continents. A total of 15,686 patients were included in this analysis. Of them, 810 (5.2%) subjects had a COPD diagnosis. They were more often elderly and with a more pronounced cardiovascular risk profile. No preminent procedural dissimilarities were noticed except for a lower proportion of dual antiplatelet therapy at discharge among COPD patients (98.9% vs. 98.1%, P = 0.038). With regards to short-term fatal outcomes, both in-hospital and 30-days mortality occurred more frequently among COPD patients, similarly in pre-COVID-19 and COVID-19 era. However, after adjustment for main baseline differences, COPD did not result as independent predictor for in-hospital death (adjusted OR [95% CI] = 0.913[0.658-1.266], P = 0.585) nor for 30-days mortality (adjusted OR [95% CI] = 0.850 [0.620-1.164], P = 0.310). No significant differences were detected in terms of SARS-CoV-2 positivity between the two groups. This is one of the largest studies investigating characteristics and outcome of COPD patients with STEMI undergoing primary angioplasty, especially during COVID pandemic. COPD was associated with significantly higher rates of in-hospital and 30-days mortality. However, this association disappeared after adjustment for baseline characteristics. Furthermore, COPD did not significantly affect SARS-CoV-2 positivity. NCT04412655 (2nd June 2020).
YR 2022
FD 2022-08-15
LK http://hdl.handle.net/10668/20315
UL http://hdl.handle.net/10668/20315
LA en
DS RISalud
RD Apr 12, 2025