RT Journal Article
T1 Pandemic 2009 A(H1N1) infection requiring hospitalization of elderly Spanish adults.
A1 Paño-Pardo, José Ramón
A1 Viasus, Diego
A1 Pachón, Jerónimo
A1 Campins, Antoni
A1 López-Medrano, Francisco
A1 Villoslada, Aroa
A1 Gutiérrez-Cuadra, Manuel
A1 Pumarola, Tomás
A1 Toro, María Dolores del
A1 Oteo, José A
A1 Martínez-Montauti, Joaquin
A1 Gutiérrez-Aroca, Juan
A1 Segura, Ferrán
A1 Carratalà, Jordi
K1 Elderly
K1 Influenza
K1 H1N1
K1 Clinical features
K1 Prognosis
K1 Antivirales
K1 Disnea
K1 Subtipo H1N1 del Virus de la Influenza A
K1 Mialgia
K1 Neumonía
K1 Estudios Prospectivos
K1 Sistema Respiratorio
K1 España
AB To describe the clinical presentation and prognosis of elderly adults hospitalized with pandemic 2009 A(H1N1) influenza infection and to compare these data with those of younger patients.DESIGN:Prospective, observational, multicenter study.SETTING:Thirteen hospitals in Spain.PARTICIPANTS:Adults admitted to the hospital with confirmed pandemic 2009 A(H1N1) influenza infection.MEASUREMENTS:Demographic, clinical, laboratory, radiological, and outcome variables.RESULTS:Between June 12 and November 10, 2009, 585 adults with confirmed 2009 A(H1N1) influenza were hospitalized, of whom 50 (8.5%) were aged 65 and older (median age 72, range 65-87). Older adults (≥ 65) were more likely to have associated comorbidities (88.0% vs 51.2%; P < .001), primarily chronic pulmonary diseases (46.0% vs 27.3%; P < .001). Lower respiratory tract symptoms and signs such as dyspnea (60.0% vs 45.6%) and wheezing (46.0% vs 27.8%; P = .007) were also more common in these elderly adults, although pulmonary infiltrates were present in just 14 (28.0%) of the older adults, compared with 221 (41.3%) of the younger adults (P = .06). Multilobar involvement was less frequent in elderly adults with pulmonary infiltrates than younger adults with pulmonary infiltrates (21.4% vs 60.0%; P = .05). Rhinorrhea (4.0% vs 21.9%; P = .003), myalgias (42.0% vs 59.1%; P = .01), and sore throat (14.0% vs 29.2%; P = .02) were more frequent in younger adults. Early antiviral therapy (<48 hours) was similar in the two groups (34.0% vs 37.9%; P = .58). Two older adults (4.0%) died during hospitalization, compared with 11 (2.1%) younger adults (P = .30).CONCLUSION:Elderly adults with 2009 A(H1N1) influenza had fewer viral-like upper respiratory symptoms than did younger adults. Pneumonia was more frequent in younger adults. No significant differences were observed in hospital mortality.
PB American Society for Microbiology
SN 0002-8614
YR 2012
FD 2012-04
LK http://hdl.handle.net/10668/2006
UL http://hdl.handle.net/10668/2006
LA en
NO Paño-Pardo JR, Viasus D, Pachón J, Campins A, López-Medrano F, Villoslada A, et al. Pandemic 2009 A(H1N1) infection requiring hospitalization of elderly Spanish adults. J Am Geriatr Soc. 2012 ; 60(4):740-4
DS RISalud
RD Apr 8, 2025