%0 Journal Article
%A Paño-Pardo, José Ramón
%A Viasus, Diego
%A Pachón, Jerónimo
%A Campins, Antoni
%A López-Medrano, Francisco
%A Villoslada, Aroa
%A Gutiérrez-Cuadra, Manuel
%A Pumarola, Tomás
%A Toro, María Dolores del
%A Oteo, José A
%A Martínez-Montauti, Joaquin
%A Gutiérrez-Aroca, Juan
%A Segura, Ferrán
%A Carratalà, Jordi
%T Pandemic 2009 A(H1N1) infection requiring hospitalization of elderly Spanish adults.
%D 2012
%@ 0002-8614
%U http://hdl.handle.net/10668/2006
%X To describe the clinical presentation and prognosis of elderly adults hospitalized with pandemic 2009 A(H1N1) influenza infection and to compare these data with those of younger patients.DESIGN:Prospective, observational, multicenter study.SETTING:Thirteen hospitals in Spain.PARTICIPANTS:Adults admitted to the hospital with confirmed pandemic 2009 A(H1N1) influenza infection.MEASUREMENTS:Demographic, clinical, laboratory, radiological, and outcome variables.RESULTS:Between June 12 and November 10, 2009, 585 adults with confirmed 2009 A(H1N1) influenza were hospitalized, of whom 50 (8.5%) were aged 65 and older (median age 72, range 65-87). Older adults (≥ 65) were more likely to have associated comorbidities (88.0% vs 51.2%; P < .001), primarily chronic pulmonary diseases (46.0% vs 27.3%; P < .001). Lower respiratory tract symptoms and signs such as dyspnea (60.0% vs 45.6%) and wheezing (46.0% vs 27.8%; P = .007) were also more common in these elderly adults, although pulmonary infiltrates were present in just 14 (28.0%) of the older adults, compared with 221 (41.3%) of the younger adults (P = .06). Multilobar involvement was less frequent in elderly adults with pulmonary infiltrates than younger adults with pulmonary infiltrates (21.4% vs 60.0%; P = .05). Rhinorrhea (4.0% vs 21.9%; P = .003), myalgias (42.0% vs 59.1%; P = .01), and sore throat (14.0% vs 29.2%; P = .02) were more frequent in younger adults. Early antiviral therapy (<48 hours) was similar in the two groups (34.0% vs 37.9%; P = .58). Two older adults (4.0%) died during hospitalization, compared with 11 (2.1%) younger adults (P = .30).CONCLUSION:Elderly adults with 2009 A(H1N1) influenza had fewer viral-like upper respiratory symptoms than did younger adults. Pneumonia was more frequent in younger adults. No significant differences were observed in hospital mortality.
%K Elderly
%K Influenza
%K H1N1
%K Clinical features
%K Prognosis
%K Antivirales
%K Disnea
%K Subtipo H1N1 del Virus de la Influenza A
%K Mialgia
%K Neumonía
%K Estudios Prospectivos
%K Sistema Respiratorio
%K España
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