TY - JOUR AU - Tristan-Manzano, Maria AU - Maldonado-Perez, Noelia AU - Justicia-Lirio, Pedro AU - Muñoz, Pilar AU - Cortijo-Gutierrez, Marina AU - Pavlovic, Kristina AU - Jimenez-Moreno, Rosario AU - Nogueras, Sonia AU - Carmona, M Dolores AU - Sanchez-Hernandez, Sabina AU - Aguilar-Gonzalez, Araceli AU - Castella, Maria AU - Juan, Manel AU - Marañon, Concepcion AU - Marchal, Juan Antonio AU - Benabdellah, Karim AU - Herrera, Concha AU - Martin, Francisco PY - 2022 DO - 10.1016/j.omto.2022.05.003 SN - 2372-7705 UR - http://hdl.handle.net/10668/22464 T2 - Molecular therapy oncolytics AB - Anti-CD19 chimeric antigen receptor (CAR)-T cells have achieved impressive outcomes for the treatment of relapsed and refractory B-lineage neoplasms. However, important limitations still remain due to severe adverse events (i.e., cytokine release... LA - en PB - Cell Press KW - CAR-T KW - T cells phenotype KW - TCR-like expression KW - WAS gene promoter KW - Exhaustion KW - Lentiviral vectors KW - Leukemia KW - Lymphoma KW - Physiological expression KW - Tonic signaling TI - Physiological lentiviral vectors for the generation of improved CAR-T cells. TY - research article VL - 25 ER -