TY  - JOUR
AU  - Avila-Pedretti, Gabriela
AU  - Tornero, Jesús
AU  - Fernández-Nebro, Antonio
AU  - Blanco, Francisco
AU  - González-Alvaro, Isidoro
AU  - Cañete, Juan D
AU  - Maymó, Joan
AU  - Alperiz, Mercedes
AU  - Fernández-Gutiérrez, Benjamín
AU  - Olivé, Alex
AU  - Corominas, Héctor
AU  - Erra, Alba
AU  - Aterido, Adrià
AU  - López Lasanta, María
AU  - Tortosa, Raül
AU  - Julià, Antonio
AU  - Marsal, Sara
PY  - 2015
DO  - 10.1371/journal.pone.0122088
UR  - http://hdl.handle.net/10668/2268
T2  - PloS One
AB  - OBJECTIVEAnti-TNF therapies have been highly efficacious in the management of rheumatoid arthritis (RA), but 25-30% of patients do not show a significant clinical response. There is increasing evidence that genetic variation at the Fc receptor FCGR2A...
LA  - en
PB  - Public Library of Science
KW  - Antirreumáticos
KW  - Macrófagos
KW  - Polimorfismo de nucleótido único
KW  - Artritis reumatoide
KW  - Receptores de IgG
KW  - Líquido sinovial
KW  - Resultado del tratamiento
KW  - Factor de necrosis tumoral alfa
KW  - Medical Subject Headings::Chemicals and Drugs::Chemical Actions and Uses::Pharmacologic Actions::Therapeutic Uses::Antirheumatic Agents
KW  - Medical Subject Headings::Diseases::Musculoskeletal Diseases::Rheumatic Diseases::Arthritis, Rheumatoid
KW  - Medical Subject Headings::Check Tags::Female
KW  - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Primates::Haplorhini::Catarrhini::Hominidae::Humans
KW  - Medical Subject Headings::Anatomy::Cells::Phagocytes::Macrophages
KW  - Medical Subject Headings::Check Tags::Male
KW  - Medical Subject Headings::Phenomena and Processes::Genetic Phenomena::Genetic Variation::Polymorphism, Genetic::Polymorphism, Single Nucleotide
KW  - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, Immunologic::Receptors, Fc::Receptors, IgG
KW  - Medical Subject Headings::Anatomy::Musculoskeletal System::Skeleton::Joints::Joint Capsule::Synovial Membrane::Synovial Fluid
KW  - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Diagnosis::Prognosis::Treatment Outcome
KW  - Medical Subject Headings::Chemicals and Drugs::Biological Factors::Intercellular Signaling Peptides and Proteins::Tumor Necrosis Factors::Tumor Necrosis Factor-alpha
KW  - Medical Subject Headings::Named Groups::Persons::Age Groups::Adult
TI  - Variation at FCGR2A and functionally related genes is associated with the response to anti-TNF therapy in rheumatoid arthritis.
TY  - research article
ER  -