RT Journal Article
T1 Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus:AMultimodality-Based Diagnosis of Two Cases
A1 Cobo, Fernando
A1 Chamorro, Clara
A1 Ramos, Francisco
A1 Concha, Ángel
K1 Humanos
K1 Linfoma Extranodal de Células NK-T
K1 Neoplasias Nasales
K1 Herpesvirus Humano 4
K1 Diagnóstico
K1 Diagnóstico Diferencial
K1 Inmunocompetencia
K1 Autopsia
AB We report two cases of extranodal NK/T-cell lymphoma, nasal type, in immunocompetent patients without nasal cavity involvement. In the two cases, the initial presumptive diagnosis was tuberculosis and there was a rapid dissemination of the tumorwith short survival after the hospital admittance. An autopsy was performed showing infiltration in several organs including lymph nodes and mesenteric and retroperitoneal fat. Histological sections showed an angiocentric and angiodestructive growth pattern and the immunophenotype was CD45+, CD3+ (cytoplasmic), as well as Granzyme B+ and EBV+. However, CD56 expression was only positive in a case in which the molecular study showed T-cell gene rearrangement with monoclonal appearance andassociated with hemophagocytic syndrome. These cases represent rare examples of NK/T-cell lymphoma disseminated outside the nasal cavity highly aggressive that lead to the rapid death of the patients.
PB Hindawi Publishing Corporation.
SN 1687-8299
YR 2009
FD 2009
LK http://hdl.handle.net/10668/653
UL http://hdl.handle.net/10668/653
LA en
NO Cobo F, Chamorro C, Ramos F, Concha A. Extranodal NK/T-Cell Lymphoma without Nasal Cavity Involvement Associated with Epstein-Barr Virus: A Multimodality-Based Diagnosis of Two Cases.  Scholarly Research Exchange, 2009  Article ID 963781, 5 pages doi:10.3814/2009/963781
DS RISalud
RD Apr 9, 2025