RT Journal Article
T1 Plasma concentrations of oleoylethanolamide in a primary care sample of depressed patients are increased in those treated with selective serotonin reuptake inhibitor-type antidepressants.
A1 Romero-Sanchiz, Pablo
A1 Nogueira-Arjona, Raquel
A1 Pastor, Antoni
A1 Araos, Pedro
A1 Serrano, Antonia
A1 Boronat, Anna
A1 Garcia-Marchena, Nuria
A1 Mayoral, Fermin
A1 Bordallo, Antonio
A1 Alen, Francisco
A1 Suárez, Juan
A1 de la Torre, Rafael
A1 Pavón, Francisco J
A1 Rodríguez de Fonseca, Fernando
K1 Acylethanolamides
K1 Anandamide
K1 Antidepressants
K1 Depression
K1 Endocannabinoids
K1 Oleoylethanolamide
K1 Primary care
AB Oleoylethanolamide (OEA) is a non-cannabinoid acylethanolamide with multiple physiological roles that has been proposed to have antidepressant-like activity in preclinical models. OEA shares biosynthetic pathways with anandamide (AEA) a transmitter involved in affective disorders and anxiety in humans. However, although the participation of OEA in depression has been proposed, both, the contribution of OEA to the depressive phenotype and the effect of antidepressant therapy on circulating levels of this and related non-cannabinoid acylethanolamides in humans are basically unknown. The main objective of this study is to compare the plasma concentrations of OEA and related acylethanolamides in a sample of primary care patients with depression (n = 69) with those of healthy non-depressed patients (n = 47). At the time of admission to the study, 22 patients were under selective serotonin reuptake inhibitor (SSRI) antidepressant treatment and 47 patients were not receiving any type of intervention. In addition, plasma concentrations of the endocannabinoid 2-AG and two related monoacylglycerols were monitored. Plasma OEA concentrations were found to be elevated in depressed patients and to correlate with somatic symptoms of depression. Plasma concentrations of both, AEA and 2-AG, were found to be elevated also in depressed patients. Further analysis demonstrated that the elevation observed in the plasma concentrations of both, OEA and 2-AG, was associated to SSRI antidepressant therapy at the time of recruitment. Further clinical research is needed to understand whether SSRI-induced elevations in OEA levels contribute to the response to SSRI in depressed patients as described in preclinical models.
YR 2019
FD 2019-02-26
LK http://hdl.handle.net/10668/13645
UL http://hdl.handle.net/10668/13645
LA en
DS RISalud
RD Apr 8, 2025