RT Journal Article
T1 Point-of-care detection of SARS-CoV-2 antigen among symptomatic vs. asymptomatic persons: Testing for COVID-19 vs. infectivity.
A1 Neukam, Karin
A1 Lucero, Alicia
A1 Gutiérrez-Valencia, Alicia
A1 Amaya, Lucas
A1 Echegoyen, Natalia
A1 Martelli, Antonella
A1 Videla, Cristina
A1 Di Lello, Federico A
A1 Martínez, Alfredo P
K1 COVID-19
K1 PCR
K1 SARS-CoV-2
K1 point-of-care
K1 public health
K1 rapid antigen testing
K1 surveillance
K1 viral kinetics
AB Management of the coronavirus disease 2019 (COVID-19) pandemic caused by a novel severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) requires rapid and simple methods to detect COVID-19 patients and identify potential infectors. This study aimed to evaluate the utility of a point-of-care (PoC) rapid antigen diagnostic test (Ag-RDT) in these settings. Individuals who consecutively presented for SARS-CoV-2 testing at a tertiary care center in Buenos Aires, Argentina, underwent PoC Ag-RDT testing and real-time RT-PCR (qRT-PCR) on the same day during June 2021. Of 584 included subjects, 108 (18.5%) were symptomatic for COVID-19 while the remaining presented for miscellaneous reasons unrelated to possible or confirmed contact with a SARS-CoV-2-infected individual. A positive Ag-RDT result was obtained in 26 (24.1%) symptomatic and 7 (1.5%) asymptomatic persons (p  PoC Ag-RDT accurately detected active SARS-CoV-2 infection and showed acceptable diagnostic performance in asymptomatic persons potentially spreading infectious virus. Ag-RDT may therefore be useful to slow down or stop transmission by enabling adequate decisions on isolation at a public health level.
YR 2022
FD 2022-10-17
LK http://hdl.handle.net/10668/20741
UL http://hdl.handle.net/10668/20741
LA en
DS RISalud
RD Apr 14, 2025