RT Journal Article
T1 Implication of Neutrophils Extracellular Traps in the Pathogenesis of SARS-CoV-2 pneumonia.
A1 Perez-Guerrero, Patricia
A1 Illanes-Alvarez, Francisco
A1 Marquez-Ruiz, Denisse
A1 Campaña-Gomez, Irene
A1 Cuesta-Sancho, Sara
A1 Marquez-Coello, Mercedes
A1 Giron-Gonzalez, Jose-Antonio
K1 COVID-19
K1 CXC chemokine ligand 4/Platelet factor 4
K1 E-selectin
K1 NETs
K1 P-selectin
AB Peripheral blood polymorphonuclear neutrophils (PMNs) forming extracellular traps (NETs), as well as endothelial- and platelet-derived parameters, have been analyzed in patients with SARS-CoV-2 pneumonia, and their prognostic role has been evaluated. Eighty-seven consecutive patients hospitalized with SARS-CoV-2 pneumonia were prospectively selected. A sample of 30 healthy individuals served as the control group. Clinical and oxygenation (oxygen saturation to fraction of inspired oxygen ratio-SpO2/FiO2) characteristics and PMNs forming NETs, serum levels of myeloperoxidase, E-selectin, vascular cell adhesion molecule 1-VCAM1-vascular endothelial growth factor, P-selectin, platelet factor 4 and plasma concentrations of D-dimer were evaluated at hospital admission, at discharge and 14 days after discharge. Intensive care unit admission or death was the primary composite endpoint. Patients showed a higher number of PMNs forming NETs than healthy controls. The absolute number of PMNs forming NETs was inversely correlated with oxygen status (SpO2/FiO2) and positively with inflammatory (C-reactive protein, ferritin) markers and VCAM1. A decrease in, but not a normalization of NETs and endothelial-derived parameters was observed in patients who survived. In conclusion, the formation of NETs runs parallel to that of other inflammatory and endothelial activation markers, and is inverse to the oxygenation parameters, supporting a pathogenic role for PMNs in this entity.
PB MDPI
SN 2227-9059
YR 2022
FD 2022-10-17
LK http://hdl.handle.net/10668/20848
UL http://hdl.handle.net/10668/20848
LA en
NO Pérez-Guerrero P, Illanes-Álvarez F, Márquez-Ruiz D, Campaña-Gómez I, Cuesta-Sancho S, Márquez-Coello M, et al. Implication of Neutrophils Extracellular Traps in the Pathogenesis of SARS-CoV-2 pneumonia. Biomedicines. 2022 Oct 20;10(10):2638
DS RISalud
RD Apr 6, 2025