RT Journal Article
T1 Sleep Apnoea Adverse Effects on Cancer: True, False, or Too Many Confounders?
A1 Gozal, David
A1 Almendros, Isaac
A1 Phipps, Amanda I.
A1 Campos-Rodriguez, Francisco
A1 Martínez-García, Miguel A.
A1 Farré, Ramon
K1 Sleep breathing disorders
K1 Malignancies
K1 Intermittent hypoxia
K1 Sleep fragmentation
K1 Apnea obstructiva del sueño
K1 Neoplasias
K1 Privación de sueño
K1 Hipoxia
AB Obstructive sleep apnoea (OSA) is a prevalent disorder associated with increased cardiovascular, metabolic and neurocognitive morbidity. Recently, an increasing number of basic, clinical and epidemiological reports have suggested that OSA may also increase the risk of cancer, and adversely impact cancer progression and outcomes. This hypothesis is convincingly supported by biological evidence linking certain solid tumours and hypoxia, as well as by experimental studies involving cell and animal models testing the effects of intermittent hypoxia and sleep fragmentation that characterize OSA. However, the clinical and epidemiological studies do not conclusively confirm that OSA adversely affects cancer, even if they hold true for specific cancers such as melanoma. It is likely that the inconclusive studies reflect that they were not specifically designed to test the hypothesis or because of the heterogeneity of the relationship of OSA with different cancer types or even sub-types. This review critically focusses on the extant basic, clinical, and epidemiological evidence while formulating proposed directions on how the field may move forward.
PB MDPI
YR 2020
FD 2020-11-20
LK http://hdl.handle.net/10668/3787
UL http://hdl.handle.net/10668/3787
LA en
NO Gozal D, Almendros I, Phipps AI, Campos-Rodriguez F, Martínez-García MA, Farré R. Sleep Apnoea Adverse Effects on Cancer: True, False, or Too Many Confounders? Int J Mol Sci. 2020 Nov 20;21(22):8779
DS RISalud
RD Apr 9, 2025