RT Journal Article
T1 Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study.
A1 Mariosa, Daniela
A1 Smith-Byrne, Karl
A1 Richardson, Tom G
A1 Ferrari, Pietro
A1 Gunter, Marc J
A1 Papadimitriou, Nikos
A1 Murphy, Neil
A1 Christakoudi, Sofia
A1 Tsilidis, Konstantinos K
A1 Riboli, Elio
A1 Muller, David
A1 Purdue, Mark P
A1 Chanock, Stephen J
A1 Hung, Rayjean J
A1 Amos, Christopher I
A1 O'Mara, Tracy A
A1 Amiano, Pilar
A1 Pasanisi, Fabrizio
A1 Rodriguez-Barranco, Miguel
A1 Krogh, Vittorio
A1 Tjønneland, Anne
A1 Halkjær, Jytte
A1 Perez-Cornago, Aurora
A1 Chirlaque, María-Dolores
A1 Skeie, Guri
A1 Rylander, Charlotta
A1 Borch, Kristin Benjaminsen
A1 Aune, Dagfinn
A1 Heath, Alicia K
A1 Ward, Heather A
A1 Schulze, Matthias
A1 Bonet, Catalina
A1 Weiderpass, Elisabete
A1 Davey Smith, George
A1 Brennan, Paul
A1 Johansson, Mattias
K1 obesity
K1 body mass index procedure
K1 cancer
K1 renal cancer
K1 attenuation
K1 cancer risk
K1 kidney
AB It is unclear if body weight in early life affects cancer risk independently of adult body weight. To investigate this question for 6 obesity-related cancers, we performed univariable and multivariable analyses using 1) Mendelian randomization (MR) analysis and 2) longitudinal analyses in prospective cohorts. Both the MR and longitudinal analyses indicated that larger early life body size was associated with higher risk of endometrial (odds ratioMR = 1.61, 95% confidence interval = 1.23 to 2.11) and kidney (odds ratioMR = 1.40, 95% confidence interval = 1.09 to 1.80) cancer. These associations were attenuated after accounting for adult body size in both the MR and cohort analyses. Early life body mass index (BMI) was not consistently associated with the other investigated cancers. The lack of clear independent risk associations suggests that early life BMI influences endometrial and kidney cancer risk mainly through pathways that are common with adult BMI.
PB Oxford University Press
YR 2022
FD 2022-03-16
LK http://hdl.handle.net/10668/19809
UL http://hdl.handle.net/10668/19809
LA en
NO Mariosa D, Smith-Byrne K, Richardson TG, Ferrari P, Gunter MJ, Papadimitriou N, et al. Body Size at Different Ages and Risk of 6 Cancers: A Mendelian Randomization and Prospective Cohort Study. J Natl Cancer Inst. 2022 Sep 9;114(9):1296-1300.
DS RISalud
RD Apr 9, 2025