RT Journal Article T1 Prognostic Value of Procalcitonin and C-Reactive Protein in 1608 Critically Ill Patients with Severe Influenza Pneumonia. A1 Carbonell, Raquel A1 Moreno, Gerard A1 Martín-Loeches, Ignacio A1 Gomez-Bertomeu, Frederic A1 Sarvisé, Carolina A1 Gómez, Josep A1 Bodí, María A1 Díaz, Emili A1 Papiol, Elisabeth A1 Trefler, Sandra A1 Nieto, Mercedes A1 Estella, Angel A1 Jiménez Herrera, María A1 Vidal Cortés, Pablo A1 Guardiola, Juan José A1 Solé-Violán, Jordi A1 Rodríguez, Alejandro K1 C-Reactive protein K1 Gram negative bacilli K1 Gram-positive cocci K1 mortality K1 pneumonia K1 procalcitonin AB Background: Procalcitonin (PCT) and C-Reactive protein (CRP) are well-established sepsis biomarkers. The association of baseline PCT levels and mortality in pneumonia remains unclear, and we still do not know whether biomarkers levels could be related to the causative microorganism (GPC, GNB). The objective of this study is to address these issues. Methods: a retrospective observational cohort study was conducted in 184 Spanish ICUs (2009-2018). Results: 1608 patients with severe influenza pneumonia with PCT and CRP available levels on admission were included, 1186 with primary viral pneumonia (PVP) and 422 with bacterial Co-infection (BC). Those with BC presented higher PCT levels (4.25 [0.6-19.5] versus 0.6 [0.2-2.3]ng/mL) and CRP (36.7 [20.23-118] versus 28.05 [13.3-109]mg/dL) as compared to PVP (p SN 2079-6382 YR 2021 FD 2021-03-26 LK https://hdl.handle.net/10668/25062 UL https://hdl.handle.net/10668/25062 LA en DS RISalud RD Apr 7, 2025