TY  - JOUR
AU  - Sheffield, Nathan C
AU  - Pierron, Gaelle
AU  - Klughammer, Johanna
AU  - Datlinger, Paul
AU  - Schönegger, Andreas
AU  - Schuster, Michael
AU  - Hadler, Johanna
AU  - Surdez, Didier
AU  - Guillemot, Delphine
AU  - Lapouble, Eve
AU  - Freneaux, Paul
AU  - Champigneulle, Jacqueline
AU  - Bouvier, Raymonde
AU  - Walder, Diana
AU  - Ambros, Ingeborg M
AU  - Hutter, Caroline
AU  - Sorz, Eva
AU  - Amaral, Ana T
AU  - de Álava, Enrique
AU  - Schallmoser, Katharina
AU  - Strunk, Dirk
AU  - Rinner, Beate
AU  - Liegl-Atzwanger, Bernadette
AU  - Huppertz, Berthold
AU  - Leithner, Andreas
AU  - de Pinieux, Gonzague
AU  - Terrier, Philippe
AU  - Laurence, Valérie
AU  - Michon, Jean
AU  - Ladenstein, Ruth
AU  - Holter, Wolfgang
AU  - Windhager, Reinhard
AU  - Dirksen, Uta
AU  - Ambros, Peter F
AU  - Delattre, Olivier
AU  - Kovar, Heinrich
AU  - Bock, Christoph
AU  - Tomazou, Eleni M
PY  - 2017
DO  - 10.1038/nm.4273
UR  - http://hdl.handle.net/10668/10818
T2  - Nature medicine
AB  - Developmental tumors in children and young adults carry few genetic alterations, yet they have diverse clinical presentation. Focusing on Ewing sarcoma, we sought to establish the prevalence and characteristics of epigenetic heterogeneity in...
LA  - en
KW  - Adolescent
KW  - Adult
KW  - Bone Neoplasms
KW  - Cell Line, Tumor
KW  - Child
KW  - Child, Preschool
KW  - DNA Methylation
KW  - Epigenesis, Genetic
KW  - Female
KW  - Gene Expression Regulation, Neoplastic
KW  - Genetic Heterogeneity
KW  - Humans
KW  - Male
KW  - Middle Aged
KW  - Oncogene Proteins, Fusion
KW  - Promoter Regions, Genetic
KW  - Proto-Oncogene Protein c-fli-1
KW  - RNA-Binding Protein EWS
KW  - Sarcoma, Ewing
KW  - Young Adult
TI  - DNA methylation heterogeneity defines a disease spectrum in Ewing sarcoma.
TY  - research article
VL  - 23
ER  -