RT Journal Article
T1 Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ.
A1 Gomez-Jaramillo, Laura
A1 Cano-Cano, Fatima
A1 Sanchez-Fernandez, Elena M
A1 Ortiz Mellet, Carmen
A1 Garcia-Fernandez, Jose M
A1 Alcala, Martin
A1 Alvarez-Gallego, Fabiola
A1 Iturregui, Marta
A1 Gonzalez-Montelongo, Maria Del Carmen
A1 Campos-Caro, Antonio
A1 Arroba, Ana I
A1 Aguilar-Diosdado, Manuel
K1 (Ss)-DS-ONJ
K1 Autophagy
K1 Diabetic nephropathy
K1 Epithelial mesenchymal transition
K1 Inflammation
K1 Área de Gestión Sanitaria de Jerez, Costa Noroeste y Sierra de Cádiz
AB Inflammatory processes play a central role in the pathogenesis of diabetic nephropathy (DN) in the early stages of the disease. The authors demonstrate that the glycolipid mimetic (Ss)-DS-ONJ is able to abolish inflammation via the induction of autophagy flux and provokes the inhibition of inflammasome complex in ex vivo and in vitro models, using adult kidney explants from BB rats. The contribution of (Ss)-DS-ONJ to reducing inflammatory events is mediated by the inhibition of classical stress kinase pathways and the blocking of inflammasome complex activation. The (Ss)-DS-ONJ treatment is able to inhibit the epithelial-to-mesenchymal transition (EMT) progression, but only when the IL18 levels are reduced by the treatment. These findings suggest that (Ss)-DS-ONJ could be a novel, and multifactorial treatment for DN.
PB MDPI
YR 2022
FD 2022-07-28
LK http://hdl.handle.net/10668/21181
UL http://hdl.handle.net/10668/21181
LA en
NO Gómez-Jaramillo L, Cano-Cano F, Sánchez-Fernández EM, Ortiz Mellet C, García-Fernández JM, Alcalá M, et al. Unravelling the Inflammatory Processes in the Early Stages of Diabetic Nephropathy and the Potential Effect of (Ss)-DS-ONJ. Int J Mol Sci. 2022 Jul 30;23(15):8450
DS RISalud
RD Apr 7, 2025