RT Journal Article
T1 Her2-Positive and Microsatellite Instability Status in Gastric Cancer-Clinicopathological Implications.
A1 Bermúdez, Ana
A1 Arranz-Salas, Isabel
A1 Mercado, Silvia
A1 López-Villodres, Juan A
A1 González, Virginia
A1 Ríus, Francisca
A1 Ortega, María V
A1 Alba, Carmen
A1 Hierro, Isabel
A1 Bermúdez, Diego
K1 HER2
K1 clinicopathological features
K1 gastric cancer
K1 microsatellite instability
K1 molecular classification
AB Gastric cancer (GC) is one of the leading causes of cancer-related death. The combination of new molecular classifications with clinicopathological data could contribute to the individualization of patients and to the development of new therapeutic strategies. We examined the various associations in two molecular types of GC: HER2-positive (human epidermal growth factor receptor 2) and microsatellite instability (MSI), assessing their influence on treatment and prognosis. A retrospective study of 142 GC patients was performed with molecular characterization through HER2 overexpression and DNA repair protein expression for MSI. The percentage of HER2-positive tumors was 13.4%, predominantly in men. Correlations were found with intestinal type, metastases, advanced stages and chemotherapy. Almost 75% of HER2-positive patients died. MSI occurred in 16.2%, associated with advanced age, female sex, distal location and intestinal type. These patients had few metastases and low stages. The percentage of deaths was higher among MSI patients who received perioperative chemotherapy. The determination of HER2 and MSI status in GC is important for their association with specific clinicopathological features and for their prognostic and predictive value.
SN 2075-4418
YR 2021
FD 2021-05-25
LK https://hdl.handle.net/10668/27036
UL https://hdl.handle.net/10668/27036
LA en
DS RISalud
RD Apr 11, 2025