RT Journal Article
T1 A Genome-Wide Association Study of Upper Aerodigestive Tract Cancers Conducted within the INHANCE Consortium
A1 McKay, James D.
A1 Truong, Therese
A1 Gaborieau, Valerie
A1 Chabrier, Amelie
A1 Chuang, Shu-Chun
A1 Byrnes, Graham
A1 Zaridze, David
A1 Shangina, Oxana
A1 Szeszenia-Dabrowska, Neonila
A1 Lissowska, Jolanta
A1 Rudnai, Peter
A1 Castellsagué, Xavier
A1 Arzani, Dario
A1 Lowry, Ray
A1 Conway, David I.
A1 Oszutowska, Dorota
A1 McKinney, Patricia A.
A1 Healy, Claire M.
A1 Toner, Mary E.
A1 Curado, Maria Paula
A1 Menezes, Ana
A1 Chen, Chu
A1 Wünsch-Filho, Victor
A1 Olshan, Andrew F.
A1 Eluf Neto, José
A1 Fernández Garrote, Leticia
A1 Boccia, Stefania
A1 Cadoni, Gabriella
A1 Weissler, Mark C.
A1 Zhang, Zuo-Feng
A1 Funkhouser, William K.
A1 Schwartz, Stephen M.
A1 McClean, Michael D.
A1 Luo, Jingchun
A1 Lubiński, Jan
A1 Trubicka, Joanna
A1 Lener, Marcin
A1 Fish, Sherianne
A1 Doody, David R.
A1 Manni, Johannes J.
A1 Muscat, Joshua E.
A1 Lazarus, Philip
A1 Gallagher, Carla J.
A1 Chang, Shen-Chih
A1 Wei, Qingyi
A1 Hung, Rayjean J.
A1 Sturgis, Erich M.
A1 Marsit, Carmen J.
A1 Wang, Li-E
A1 Franceschi, Silvia
A1 Herrero, Rolando
A1 Kelsey, Karl T.
A1 Nelson, Heather H.
A1 Vineis, Paolo
A1 Romkes, Marjorie
A1 Peters, Wilbert H. M.
A1 Quirós, J. Ramón
A1 Buch, Shama
A1 Nukui, Tomoko
A1 Zhong, Shilong
A1 Lacko, Martin
A1 McLaughlin, John
A1 Vatten, Lars
A1 Trichopoulou, Antonia
A1 Njølstad, Inger
A1 Goodman, Gary E.
A1 Field, John K.
A1 Liloglou, Triantafillos
A1 Clavel-Chapelon, Francoise
A1 Boeing, Heiner
A1 Palli, Domenico
A1 Martínez, Carmen
A1 Tumino, Rosario
A1 Krogh, Vittorio
A1 Panico, Salvatore
A1 González, Carlos A.
A1 Navarro, Carmen
A1 Voodern, Tõnu
A1 Ardanaz, Eva
A1 Linseisen, Jakob
A1 Blanché, Hélène
A1 Khaw, Kay-Tee
A1 Key, Timothy
A1 Bueno-de-Mesquita, Bas
A1 Peeters, Petra H. M.
A1 Hallmans, Göran
A1 Overvad, Kim
A1 Bucur, Alexandru
A1 Tjønneland, Anne
A1 Kumle, Merethe
A1 Riboli, Elio
A1 Välk, Kristjan
A1 Metspalu, Andres
A1 Janout, Vladimir
A1 Zelenika, Diana
A1 Gut, Ivo G.
A1 Boland, Anne
A1 Delepine, Marc
A1 Foglio, Mario
A1 Lechner, Doris
A1 Galan, Pilar
A1 Merletti, Franco
A1 Heath, Simon
A1 Bencko, Vladimir
A1 Canova, Cristina
A1 Hayes, Richard B.
A1 Boffetta, Paolo
A1 Lathrop, Mark
A1 Brennan, Paul
A1 Foretova, Lenka
A1 Lagiou, Pagona
A1 Richiardi, Lorenzo
A1 Trichopoulos, Dimitrios
A1 Benhamou, Simone
A1 Bouchardy, Christine
A1 Ahrens, Wolfgang
A1 Talamini, Renato
A1 Koifman, Sergio
A1 Barzan, Luigi
A1 Agudo, Antonio
A1 Kjaerheim, Kristina
A1 Macfarlane, Gary J.
A1 Macfarlane, Tatiana V.
A1 Simonato, Lorenzo
K1 Estudio de Asociación del Genoma Completo
K1 Neoplasias de Cabeza y Cuello
K1 Estudio Multicéntrico
K1 INHANCE Consortium
AB Genome-wide association studies (GWAS) have been successful in identifying common genetic variation involved in susceptibility to etiologically complex disease. We conducted a GWAS to identify common genetic variation involved in susceptibility to upper aero-digestive tract (UADT) cancers. Genome-wide genotyping was carried out using the Illumina HumanHap300 beadchips in 2,091 UADT cancer cases and 3,513 controls from two large European multi-centre UADT cancer studies, as well as 4,821 generic controls. The 19 top-ranked variants were investigated further in an additional 6,514 UADT cancer cases and 7,892 controls of European descent from an additional 13 UADT cancer studies participating in the INHANCE consortium. Five common variants presented evidence for significant association in the combined analysis (p≤5×10−7). Two novel variants were identified, a 4q21 variant (rs1494961, p = 1×10−8) located near DNA repair related genes HEL308 and FAM175A (or Abraxas) and a 12q24 variant (rs4767364, p = 2×10−8) located in an extended linkage disequilibrium region that contains multiple genes including the aldehyde dehydrogenase 2 (ALDH2) gene. Three remaining variants are located in the ADH gene cluster and were identified previously in a candidate gene study involving some of these samples. The association between these three variants and UADT cancers was independently replicated in 5,092 UADT cancer cases and 6,794 controls non-overlapping samples presented here (rs1573496-ADH7, p = 5×10−8; rs1229984-ADH1B, p = 7×10−9; and rs698-ADH1C, p = 0.02). These results implicate two variants at 4q21 and 12q24 and further highlight three ADH variants in UADT cancer susceptibility.
PB Public Library of Science
YR 2011
FD 2011-03-17
LK http://hdl.handle.net/10668/252
UL http://hdl.handle.net/10668/252
LA en
NO McKay JD, Truong T, Gaborieau V, Chabrier A, Chuang SC, Byrnes G, et al. A genome-wide association study of upper aerodigestive tract cancers conducted within the INHANCE consortium. PLoS Genet. 2011 Mar; 7 (3) :e1001333
DS RISalud
RD Apr 19, 2025