TY  - JOUR
AU  - Gonzalez, Veronica D
AU  - Huang, Ying-Wen
AU  - Delgado-Gonzalez, Antonio
AU  - Chen, Shih-Yu
AU  - Donoso, Kenyi
AU  - Sachs, Karen
AU  - Gentles, Andrew J
AU  - Allard, Grace M
AU  - Kolahi, Kevin S
AU  - Howitt, Brooke E
AU  - Porpiglia, Ermelinda
AU  - Fantl, Wendy J
PY  - 2021
DO  - 10.1016/j.celrep.2021.109632
UR  - https://hdl.handle.net/10668/27816
T2  - Cell reports
AB  - Tubo-ovarian high-grade serous carcinoma (HGSC) is unresponsive to immune checkpoint blockade despite significant frequencies of exhausted T cells. Here we apply mass cytometry and uncover decidual-like natural killer (dl-NK) cell subpopulations...
LA  - en
KW  - CD9
KW  - HGSC
KW  - NK cells
KW  - NK immunotherapy
KW  - T cells
KW  - cytokine production
KW  - cytotoxicity
KW  - decidual-like
KW  - epithelial tumor
KW  - epithelial-mesenchymal
KW  - high-grade serous carcinoma
KW  - immune infiltrate
KW  - immune tolerance
KW  - trogocytosis
KW  - tubo-ovarian tumor
KW  - Antineoplastic Agents
KW  - Carboplatin
KW  - Cell Line, Tumor
KW  - Coculture Techniques
KW  - Cytokines
KW  - Cytotoxicity, Immunologic
KW  - Female
KW  - Humans
KW  - Immune Tolerance
KW  - Killer Cells, Natural
KW  - Lymphocytes, Tumor-Infiltrating
KW  - Neoplasms, Cystic, Mucinous, and Serous
KW  - Ovarian Neoplasms
KW  - Phenotype
KW  - Receptors, Natural Killer Cell
KW  - Tetraspanin 29
KW  - Trogocytosis
KW  - Tumor Escape
KW  - Tumor Microenvironment
TI  - High-grade serous ovarian tumor cells modulate NK cell function to create an immune-tolerant microenvironment.
TY  - research article
VL  - 36
ER  -