TY - JOUR AU - Castilla-Ortega, Estela AU - Hoyo-Becerra, Carolina AU - Pedraza, Carmen AU - Chun, Jerold AU - Rodríguez de Fonseca, Fernando AU - Estivill-Torrús, Guillermo AU - Santín, Luis J PY - 2011 DO - 10.1371/journal.pone.0025522 UR - http://hdl.handle.net/10668/698 T2 - PloS one AB - BACKGROUNDThe lysophosphatidic acid LPA₁ receptor regulates plasticity and neurogenesis in the adult hippocampus. Here, we studied whether absence of the LPA₁ receptor modulated the detrimental effects of chronic stress on hippocampal neurogenesis and... LA - en PB - Public Library of Science KW - Animales KW - Ansiedad KW - recuento de células KW - proliferación celular KW - Supervivencia Celular KW - Conducta Exploratoria KW - técnicas de inactivación genética KW - Hipocampo KW - Masculino KW - Memoria KW - Ratones KW - proteínas asociadas a microtúbulos KW - células madre nerviosas KW - Neurogénesis KW - Neuronas KW - Neuroglía KW - tamaño de los órganos KW - receptores de ácidos lisofosfatídicos KW - restricción física KW - Conducta Espacial KW - Estrés Psicológico KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Emotions::Anxiety KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Death::Apoptosis KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Count KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Growth Processes::Cell Proliferation KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Survival KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Exploratory Behavior KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Genetic Techniques::Gene Targeting::Gene Knockout Techniques KW - Medical Subject Headings::Anatomy::Nervous System::Central Nervous System::Brain::Limbic System::Hippocampus KW - Medical Subject Headings::Check Tags::Male KW - Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Memory KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Neurobehavioral Manifestations::Memory Disorders KW - Medical Subject Headings::Psychiatry and Psychology::Psychological Phenomena and Processes::Mental Processes::Learning::Memory::Memory, Short-Term KW - Medical Subject Headings::Organisms::Eukaryota::Animals::Chordata::Vertebrates::Mammals::Rodentia::Muridae::Murinae::Mice KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Cytoskeletal Proteins::Microtubule Proteins::Microtubule-Associated Proteins KW - Medical Subject Headings::Anatomy::Cells::Stem Cells::Neural Stem Cells KW - Medical Subject Headings::Phenomena and Processes::Cell Physiological Phenomena::Cell Physiological Processes::Cell Differentiation::Neurogenesis KW - Medical Subject Headings::Anatomy::Cells::Neuroglia KW - Medical Subject Headings::Anatomy::Nervous System::Neurons KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Peptides::Neuropeptides KW - Medical Subject Headings::Phenomena and Processes::Physiological Phenomena::Physiological Processes::Growth and Development::Growth::Organ Size KW - Medical Subject Headings::Chemicals and Drugs::Amino Acids, Peptides, and Proteins::Proteins::Membrane Proteins::Receptors, Cell Surface::Receptors, G-Protein-Coupled::Receptors, Lysophospholipid::Receptors, Lysophosphatidic Acid KW - Medical Subject Headings::Analytical, Diagnostic and Therapeutic Techniques and Equipment::Investigative Techniques::Immobilization::Restraint, Physical KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Spatial Behavior KW - Medical Subject Headings::Psychiatry and Psychology::Behavior and Behavior Mechanisms::Behavior::Behavioral Symptoms::Stress, Psychological KW - Medical Subject Headings::Organisms::Eukaryota::Animals TI - Aggravation of chronic stress effects on hippocampal neurogenesis and spatial memory in LPA₁ receptor knockout mice. TY - research article ER -