RT Journal Article
T1 Two Healthy Diets Modulate Gut Microbial Community Improving Insulin Sensitivity in a Human Obese Population.
A1 Haro, Carmen
A1 Montes-Borrego, Miguel
A1 Rangel-Zuñiga, Oriol A
A1 Alcala-Diaz, Juan F
A1 Gomez-Delgado, Francisco
A1 Perez-Martinez, Pablo
A1 Delgado-Lista, Javier
A1 Quintana-Navarro, Gracia M
A1 Tinahones, Francisco J
A1 Landa, Blanca B
A1 Lopez-Miranda, Jose
A1 Camargo, Antonio
A1 Perez-Jimenez, Francisco
K1 DNA, bacterial
K1 Diet
K1 Diet, fat-restricted
K1 Diet, mediterranean
K1 Dietary carbohydrates
AB Gut microbiota, which acts collectively as a fully integrated organ in the host metabolism, can be shaped by long-term dietary interventions after a specific diet. The aim was to study the changes in microbiota after 1 year's consumption of a Mediterranean diet (Med diet) or a low-fat, high-complex carbohydrate diet (LFHCC diet) in an obese population. Participants were randomized to receive the Med diet (35% fat, 22% monounsaturated) and the LFHCC diet (28% fat, 12% monounsaturated). The study was conducted in 20 obese patients (men) within the Coronary Diet Intervention With Olive Oil and Cardiovascular Prevention (CORDIOPREV) study, an ongoing prospective, randomized, opened, controlled trial in patients with coronary heart disease. We evaluated the bacterial composition and its relationship with the whole fecal and plasma metabolome. The LFHCC diet increased the Prevotella and decreased the Roseburia genera, whereas the Med diet decreased the Prevotella and increased the Roseburia and Oscillospira genera (P = .028, .002, and .016, respectively). The abundance of Parabacteroides distasonis (P = .025) and Faecalibacterium prausnitzii (P = .020) increased after long-term consumption of the Med diet and the LFHCC diet, respectively. The changes in the abundance of 7 of 572 metabolites found in feces, including mainly amino acid, peptide, and sphingolipid metabolism, could be linked to the changes in the gut microbiota. Our results suggest that long-term consumption of the Med and LFHCC diets exerts a protective effect on the development of type 2 diabetes by different specific changes in the gut microbiota, increasing the abundance of the Roseburia genus and F. prausnitzii, respectively.
PB Oxford University Press
YR 2015
FD 2015-10-21
LK http://hdl.handle.net/10668/10538
UL http://hdl.handle.net/10668/10538
LA en
NO Haro C, Montes-Borrego M, Rangel-Zúñiga OA, Alcalá-Díaz JF, Gómez-Delgado F, Pérez-Martínez P, et al. Two Healthy Diets Modulate Gut Microbial Community Improving Insulin Sensitivity in a Human Obese Population. J Clin Endocrinol Metab. 2016 Jan;101(1):233-42
DS RISalud
RD Apr 5, 2025