RT Journal Article
T1 Unveiling the Potential of Liquid Biopsy in HER2-Positive Breast Cancer Management.
A1 Godoy-Ortiz, Ana
A1 Alba-Bernal, Alfonso
A1 Pascual, Javier
A1 Comino-Méndez, Iñaki
A1 Alba, Emilio
K1 HER2-positive breast cancer
K1 circulating-tumour DNA
K1 circulating-tumour cells
K1 early breast cancer
K1 liquid biopsy
K1 metastatic breast cancer
AB Invasive breast cancer (BC) is the most common cancer in women with a slightly increasing yearly incidence. BC immunohistochemical characterisation is a crucial tool to define the intrinsic nature of each tumour and personalise BC patients' clinical management. In this regard, the characterisation of human epidermal growth factor receptor 2 (HER2) status guides physicians to treat with therapies tailored to this membrane receptor. Standardly, a tumour solid biopsy is therefore required, which is an invasive procedure and has difficulties to provide the complete molecular picture of the tumour. To complement these standard-of-care approaches, liquid biopsy is a validated methodology to obtain circulating tumour components such as circulating tumour DNA (ctDNA) and circulating tumour cells (CTCs) from body fluids in an easy-to-perform minimal-invasive manner. However, its clinical validity in cancer is still to be demonstrated. This review focusses on the utilisation of both ctDNA and CTCs in early and metastatic HER2-positive BC tumours. We discuss recently published studies deciphering the capacity of liquid biopsy to determine the response to neoadjuvant and adjuvant therapies as well as to predict patients' outcomes.
SN 2072-6694
YR 2022
FD 2022-01-24
LK http://hdl.handle.net/10668/20870
UL http://hdl.handle.net/10668/20870
LA en
DS RISalud
RD Apr 6, 2025