RT Journal Article
T1 Layer-Specific Global Longitudinal Strain Predicts Arrhythmic Risk in Arrhythmogenic Cardiomyopathy.
A1 Segura-Rodríguez, Diego
A1 Bermúdez-Jiménez, Francisco José
A1 González-Camacho, Lorena
A1 Moreno Escobar, Eduardo
A1 García-Orta, Rocío
A1 Alcalá-López, Juan Emilio
A1 Bautista Pavés, Alicia
A1 Oyonarte-Ramírez, José Manuel
A1 López-Fernández, Silvia
A1 Álvarez, Miguel
A1 Tercedor, Luis
A1 Jiménez-Jáimez, Juan
K1 arrhythmogenic cardiomyopathy (ACM)
K1 global longitudinal strain
K1 late gadolinium enhanced
K1 non-sustained ventricular tachycardia
K1 sudden cardiac death (SCD)
AB Background: Arrhythmogenic cardiomyopathy (AC) is a life-threatening disease which predispose to malignant arrhythmias and sudden cardiac death (SCD) in the early stages of the disease. Risk stratification relies on the electrical, genetic, and imaging data. Our study aimed to investigate how myocardial deformation parameters may identify the subjects at risk of known predictors of major ventricular arrhythmias. Methods: A cohort of 45 subjects with definite or borderline diagnosis of AC was characterized using the advanced transthoracic echocardiography (TTE) and cardiac magnetic resonance (CMR) and divided into the groups according to the potential arrhythmic risk markers, such as non-sustained ventricular tachycardia (NSVT), late gadolinium enhancement (LGE), and genetic status. Layer-specific global longitudinal strain (GLS) by TTE 2D speckle tracking was compared in patients with and without these arrhythmic risk markers. Results: In this study, 23 (51.1%) patients were men with mean age of 43 ± 16 years. Next-generation sequencing identified a potential pathogenic mutation in 39 (86.7%) patients. Thirty-nine patients presented LGE (73.3%), mostly located at the subepicardial-to-mesocardial layers. A layer-specific-GLS analysis showed worse GLS values at the epicardial and mesocardial layers in the subjects with NSVT and LGE. The epicardial GLS values of -15.4 and -16.1% were the best cut-off values for identifying the individuals with NSVT and LGE, respectively, regardless of left ventricular ejection fraction (LVEF). Conclusions: The layer-specific GLS assessment identified the subjects with high-risk arrhythmic features in AC, such as NSVT and LGE. An epicardial GLS may emerge as a potential instrument for detecting the subjects at risk of SCD in AC.
SN 2297-055X
YR 2021
FD 2021-11-15
LK https://hdl.handle.net/10668/26208
UL https://hdl.handle.net/10668/26208
LA en
DS RISalud
RD Apr 6, 2025